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Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201808234
Abstract: Antibiotic discovery has experienced a severe slowdown in terms of discovery of new candidates. In vitro screening methods using phospholipids to model the bacterial membrane provide a route to identify molecules that specifically disrupt bacterial…
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Keywords:
membrane disruption;
disruption;
biomimetic electronic;
electronic devices ... See more keywords
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Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9736-3
Abstract: Recently, there has been a growing interest in the discovery of novel chemotherapeutic agents that have fewer side effects and are less likely to develop resistance. This study was conducted to examine the antitumor activity…
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Keywords:
membrane disruption;
apoptosis;
lycosin;
tumor cells ... See more keywords
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Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00785
Abstract: The interactions of amyloid oligomers with membranes are known to contribute to cellular toxicity. Numerous in vitro experimental studies reported on the insertion of oligomers of different sizes that can induce cell membrane disruption, extract…
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Keywords:
membrane disruption;
disruption;
shaped cross;
cross hexamer ... See more keywords
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Published in 2023 at "Membranes"
DOI: 10.3390/membranes13020251
Abstract: We investigated the antimicrobial activity and membrane disruption modes of the antimicrobial peptide mastoparan-AF against hemolytic Escherichia coli O157:H7. Based on the physicochemical properties, mastoparan-AF may potentially adopt a 3–11 amphipathic helix-type structure, with five…
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Keywords:
coli o157;
mastoparan;
membrane disruption;
membrane ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26175194
Abstract: Necroptosis is a type of programmed cell death executed through the plasma membrane disruption by mixed lineage kinase domain-like protein (MLKL). Previous studies have revealed that an N-terminal four-helix bundle domain (NBD) of MLKL is…
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Keywords:
membrane disruption;
disruption;
mlkl;
necroptosis ... See more keywords
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Published in 2023 at "Nanomaterials"
DOI: 10.3390/nano13050874
Abstract: In light of regulatory considerations, there are ongoing efforts to identify Triton X-100 (TX-100) detergent alternatives for use in the biological manufacturing industry to mitigate membrane-enveloped pathogen contamination. Until now, the efficacy of antimicrobial detergent…
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Keywords:
lipid membrane;
100 detergent;
spectroscopy;
membrane disruption ... See more keywords