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   Articles with "membrane fusion" as a keyword



Epigallocatechin gallate inhibits SNARE‐dependent membrane fusion by blocking trans‐SNARE assembly

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13488

Abstract: Insulin secretion is a signal‐triggered process that requires membrane fusion between the secretory granules and plasma membrane in pancreatic β cells. The exocytosis of insulin is mediated by target‐soluble N‐ethylmaleimide sensitive factor attachment protein receptors… read more here.

Keywords: trans snare; fusion; membrane fusion; snare dependent ... See more keywords

Acidic pH-Triggered Membrane Fusion Enables Lyophilized Lipid Nanoparticles as Potent Cryoprotectants for Human Erythrocytes.

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recommendations! Published in 2025 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202502455

Abstract: The cryopreservation of human red blood cells (RBCs) is essential for maintaining a stable blood supply, but current glycerol‐based methods are hindered by complex and time‐consuming post‐thaw processing. While trehalose is a promising biocompatible cryoprotectant,… read more here.

Keywords: membrane fusion; acidic triggered; fusion; triggered membrane ... See more keywords

Enhanced Liposomal Drug Delivery Via Membrane Fusion Triggered by Dimeric Coiled-Coil Peptides.

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recommendations! Published in 2023 at "Small"

DOI: 10.1002/smll.202301133

Abstract: An ideal nanomedicine system improves the therapeutic efficacy of drugs. However, most nanomedicines enter cells via endosomal/lysosomal pathways and only a small fraction of the cargo enters the cytosol inducing therapeutic effects. To circumvent this… read more here.

Keywords: membrane fusion; fusion; delivery; coiled coil ... See more keywords

Analysis of Mitochondrial Membrane Fusion GTPase OPA1 Expressed by the Silkworm Expression System.

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recommendations! Published in 2020 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0676-6_9

Abstract: Mitochondria are highly dynamic organelles, which move and fuse to regulate their shape, size, and fundamental function. The dynamin-related GTPases play a critical role in mitochondrial membrane fusion. In vitro reconstitution of membrane fusion using… read more here.

Keywords: opa1; membrane fusion; expression; fusion ... See more keywords

Membrane Fusion Assays for Studying Entry Hepatitis C Virus into Cells.

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recommendations! Published in 2019 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-8976-8_15

Abstract: The membrane fusion properties of HCV envelope glycoproteins can be evaluated using several assays. Fusion assays generally require contacts between glycoproteins expressed on a donor membrane, such as those from a cell or a viral… read more here.

Keywords: fusion assays; membrane fusion; virus; fusion ... See more keywords

Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level

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recommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"

DOI: 10.1016/j.csbj.2021.08.053

Abstract: The membrane fusion mechanism of SARS-CoV-2 offers an attractive target for the development of small molecule antiviral inhibitors. Fusion involves an initial binding of the crown-like trimeric spike glycoproteins of SARS-CoV-2 to the receptor angiotensin… read more here.

Keywords: fusion mechanism; membrane fusion; fusion; sars cov ... See more keywords

Aloperine inhibits hepatitis C virus entry into cells by disturbing internalisation from endocytosis to the membrane fusion process.

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recommendations! Published in 2020 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2020.173323

Abstract: Aloperine, a natural alkaloid isolated from the Chinese traditional herb Sophora alopecuroides, is a broad-spectrum antiviral agent with anti-inflammatory activity. Here, we found that aloperine effectively inhibited hepatitis C virus (HCV) propagation in Huh7.5 cells and… read more here.

Keywords: internalisation endocytosis; membrane fusion; fusion process; aloperine inhibits ... See more keywords

Inhibition of HIV-1 envelope-dependent membrane fusion by serum antilymphocyte autoantibodies is associated with low plasma viral load.

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recommendations! Published in 2019 at "Immunology letters"

DOI: 10.1016/j.imlet.2019.05.002

Abstract: The HIV-1 envelope protein (Env) mediates the membrane fusion process allowing virus entry to target cells and the efficiency to induce membrane fusion is an important determinant of HIV-1 pathogenicity. In addition to virus receptors,… read more here.

Keywords: hiv; cd4 negative; membrane fusion; fusion ... See more keywords
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Membrane protein density determining membrane fusion revealed by dynamic fluorescence imaging.

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recommendations! Published in 2021 at "Talanta"

DOI: 10.1016/j.talanta.2021.122091

Abstract: Membrane fusion is fundamental to biological activity of cells, so disclosingits relevant mechanism is very important for understanding various cell functions. Although artificial model systems have been developed to uncover the mechanism of membrane fusion,… read more here.

Keywords: density; membrane; membrane protein; membrane fusion ... See more keywords

Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+ Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00061

Abstract: We previously reported that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) 4 functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand induces paraptosis, a relatively newly found programmed cell death, in cancer cells… read more here.

Keywords: membrane fusion; fusion mitochondria; paraptosis; cyclometalated iridium ... See more keywords

Hybrid Anticancer Peptide Synergistically Improving Cancer Cell Uptake and Inducing Apoptosis Mediated by Membrane Fusion.

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recommendations! Published in 2025 at "Biomacromolecules"

DOI: 10.1021/acs.biomac.5c00154

Abstract: Anticancer peptides (ACPs) have exhibited tremendous potential in tumor treatment. However, low peptide delivery efficiency limits some ACPs' clinical application. Herein, we designed a hybrid peptide named AFP-KLA and investigated the tumor cell-specific targeting ability… read more here.

Keywords: cell; membrane fusion; tumor; afp kla ... See more keywords