Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer
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DOI: 10.1002/advs.202105506
Abstract: Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and induction of drug resistance via stress‐induced mutagenesis. Despite continued research… read more here.
Keywords: breast cancer; triple negative; membrane lytic; cancer ... See more keywords
Glycan Alteration Imparts Cellular Resistance to a Membrane-Lytic Anticancer Peptide.
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DOI: 10.1016/j.chembiol.2016.12.009
Abstract: Although resistance toward small-molecule chemotherapeutics has been well studied, the potential of tumor cells to avoid destruction by membrane-lytic compounds remains unexplored. Anticancer peptides (ACPs) are a class of such agents that disrupt tumor cell… read more here.
Keywords: cellular resistance; membrane lytic; resistance; anticancer ... See more keywords