Antibiotic Resistance: Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA (Adv. Sci. 6/2020)
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DOI: 10.1002/advs.202070035
Abstract: In article number https://doi.org/10.1002/advs.201903117, Ji‐Xin Cheng and co‐workers report an endogenous chromophore‐based phototherapy platform to combat antibiotic‐resistance Staphylococcus aureus infections. Functional membrane microdomains of Staphylococcus aureus are catastrophically disrupted via photochemical decomposition of membrane‐bound carotenoid… read more here.
Keywords: staphylococcus aureus; conventional antibiotics; antibiotic resistance; membrane microdomains ... See more keywords
Lipid composition of membrane microdomains isolated detergent‐free from PUFA supplemented RAW264.7 macrophages
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DOI: 10.1002/jcp.26138
Abstract: Profound alterations in the lipid profile of raft and non‐raft plasma membrane microdomains were found when RAW264.7 macrophages were supplemented with polyunsaturated fatty acids (PUFAs) in physiologically relevant concentrations. For the first time lipids in… read more here.
Keywords: pufa; raw264 macrophages; raft; detergent free ... See more keywords
Isolation of Plasma Membrane and Plasma Membrane Microdomains.
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DOI: 10.1007/978-1-4939-6533-5_16
Abstract: The plasma membrane surrounds the cytoplasm of a cell and functions as a barrier to separate the intracellular compartment from the extracellular environment. Protein and lipid components distribute nonuniformly and the components form clusters with… read more here.
Keywords: isolation plasma; membrane plasma; membrane microdomains; membrane ... See more keywords
Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes
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DOI: 10.1007/978-3-319-54579-0_2
Abstract: Signaling through the diffusible second messenger, 3′,5′-cyclic adenosine monophosphate (cAMP) is critical to the regulation of cardiac function. Several different G-protein-coupled receptors, including β-adrenergic receptors, muscarinic receptors, and E-type prostaglandin receptors, elicit distinct responses using… read more here.
Keywords: cardiac myocytes; compartmentation cardiac; microdomains camp; camp compartmentation ... See more keywords
Isolation of detergent-resistant membranes (DRMs) from Escherichia coli.
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DOI: 10.1016/j.ab.2016.10.025
Abstract: Lipid rafts or membrane microdomains have been proposed to compartmentalize cellular processes by spatially organizing diverse molecules/proteins in eukaryotic cells. Such membrane microdomains were recently reported to also exist in a few bacterial species. In… read more here.
Keywords: escherichia coli; isolation detergent; membrane microdomains; isolation ... See more keywords
FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains
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DOI: 10.1038/s41598-017-01789-y
Abstract: Platelet-derived growth factor receptor (PDGFR) senses extracellular growth factors and transfer the signals inside the cells regulating cell proliferation, migration and survival. It has been controversial at which membrane microdomains PDGFRs reside and how they… read more here.
Keywords: activation; receptor; membrane microdomains; pdgfr ... See more keywords
Glycolipids: Linchpins in the Organization and Function of Membrane Microdomains
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DOI: 10.3389/fcell.2020.589799
Abstract: Membrane microdomains, also called lipid rafts, are areas on membrane enriched in glycolipids, sphingolipids, and cholesterol. Although membrane microdomains are thought to play key roles in many cellular functions, their structures, properties, and biological functions… read more here.
Keywords: linchpins organization; microdomains mediate; organization function; glycolipids linchpins ... See more keywords
Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition
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DOI: 10.3389/fcimb.2019.00074
Abstract: Antimicrobial resistance constitutes one of the major challenges facing humanity in the Twenty-First century. The spread of resistant pathogens has been such that the possibility of returning to a pre-antibiotic era is real. In this… read more here.
Keywords: toxin neutralization; therapeutic strategies; quorum sensing; anti virulence ... See more keywords
Revisiting Membrane Microdomains and Phase Separation: A Viral Perspective
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DOI: 10.3390/v12070745
Abstract: Retroviruses selectively incorporate a specific subset of host cell proteins and lipids into their outer membrane when they bud out from the host plasma membrane. This specialized viral membrane composition is critical for both viral… read more here.
Keywords: revisiting membrane; phase separation; separation viral; membrane microdomains ... See more keywords