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Published in 2020 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26063
Abstract: Promoting drug delivery across the biological membrane is a common strategy to improve bioavailability. Inspired by the observation that carbonated alcoholic beverages can increase the absorption rate of ethanol, we speculate that carbon dioxide (CO2)…
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Keywords:
permeability;
membrane permeability;
membrane;
carbon dioxide ... See more keywords
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Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101005
Abstract: Background Immortalized mammalian cell lines are a valuable research tool, though they represent a highly simplified model. Due to accumulated mutations they may not reflect characteristics of the disease or even the tissue they derive…
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Keywords:
membrane permeability;
block;
cell membrane;
seax ... See more keywords
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Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113649
Abstract: Traumatic brain injury (TBI) can produce physical disruptions in the plasma membranes of neurons, referred to as mechanoporation, which lead to increased cell permeability. We suspect that such trauma-induced membrane disruptions may be influenced by…
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Keywords:
membrane permeability;
brain;
injury;
membrane ... See more keywords
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Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113423
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Pristimerin is a triterpenoid considered the main component of Salacia crassifolia extracts. This terpene has shown promising antitumor, anti-inflammatory, and antimicrobial effects. Likewise, S. crassifolia has been used in traditional medicine to treat…
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Keywords:
agent;
membrane permeability;
pristimerin isolated;
pristimerin ... See more keywords
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Published in 2019 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2019.03.001
Abstract: The aim of this study was to investigate antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion…
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Keywords:
membrane permeability;
cell membrane;
compactum essential;
quorum sensing ... See more keywords
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Published in 2022 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2021.119556
Abstract: Abstract A comprehensive assessment of the effects of temperature on hydraulically irreversible membrane permeability in tertiary ultrafiltration of municipal wastewater was conducted through bench scale testing. The influence of temperature was differentiated into impacts on…
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Keywords:
irreversible membrane;
hydraulically irreversible;
membrane permeability;
irreversible permeability ... See more keywords
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Published in 2017 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2016.11.035
Abstract: Effects of low-intensity ultrasound (at different frequency, treatment time and power) on Saccharomyces cerevisiae in different growth phase were evaluated by the biomass in the paper. In addition, the cell membrane permeability and ethanol tolerance…
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Keywords:
membrane permeability;
saccharomyces cerevisiae;
ethanol tolerance;
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Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2016.10.006
Abstract: Previously, several aurone derivatives were identified with promising neuroprotective activities. In developing these compounds to target the central nervous system (CNS), an assessment of their blood-brain barrier (BBB) permeability was performed using in vitro BBB models:…
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Keywords:
membrane permeability;
artificial membrane;
permeability;
permeability assay ... See more keywords
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Published in 2019 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.8b00560
Abstract: Spontaneous solute and solvent permeation through membranes is of vital importance to human life, be it gas exchange in red blood cells, metabolite excretion, drug/toxin uptake, or water homeostasis. Knowledge of the underlying molecular mechanisms…
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Keywords:
membrane permeability;
permeability small;
small molecules;
intrinsic membrane ... See more keywords
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Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00803
Abstract: Cyclic peptides have the potential to bind to challenging targets, which are undruggable with small molecules, but their application is limited by low membrane permeability. Here, using a series of cyclic pentapeptides, we showed that…
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Keywords:
permeability cyclic;
membrane permeability;
permeability;
peptides modulated ... See more keywords
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Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00931
Abstract: Cyclic peptides have attracted attention as a promising pharmaceutical modality due to their potential to selectively inhibit previously undruggable targets, such as intracellular protein–protein interactions. Poor membrane permeability is the biggest bottleneck hindering successful drug…
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Keywords:
cyclic peptides;
membrane permeability;
membrane model;
membrane ... See more keywords