Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1178-z
Abstract: ObjectiveIL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and… read more here.
Keywords: secretion; vascular smooth; human vascular; lysosomal membrane ... See more keywords
Mitochondrial outer membrane permeabilization at the single molecule level
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03771-4
Abstract: Apoptotic cell death is essential for development, immune function or tissue homeostasis, and its mis-regulation is linked to various diseases. Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway and… read more here.
Keywords: molecule; single molecule; outer membrane; membrane permeabilization ... See more keywords
A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2020.10.004
Abstract: Lysosomes are placed at the center of cellular trafficking and degradative pathways. They also function as a signaling platform for nutrient sensing and metabolic reprogramming. Lysosomes play crucial roles in cellular adaptation in response to… read more here.
Keywords: microscopy; damaged lysosomes; lysosomal membrane; membrane permeabilization ... See more keywords
Aromatic-rich C-terminal region of LCI is a potent antimicrobial peptide in itself.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.013
Abstract: LCI is a 47-residue antimicrobial peptide produced by Bacillus subtilis. The peptide displays potent activity against plant pathogens, Xanthomonas and Pseudomonas. The peptide takes a compact 3-dimensional structure characterized by a four-stranded β-sheet. The peptide… read more here.
Keywords: terminal region; membrane permeabilization; peptide; antimicrobial peptide ... See more keywords
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.029
Abstract: BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and the structural determinants essential to… read more here.
Keywords: bax; pro apoptotic; membrane permeabilization; membrane ... See more keywords
Hybrid Magnetic Nanovectors Promote Selective Glioblastoma Cell Death through a Combined Effect of Lysosomal Membrane Permeabilization and Chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.0c05556
Abstract: Glioblastoma multiforme is the most aggressive brain tumor, due to its high invasiveness and genetic heterogeneity. Moreover, the blood–brain barrier prevents many drugs from reaching a therapeutic concentration at the tumor site, and most of… read more here.
Keywords: blood brain; glioblastoma; lysosomal membrane; membrane permeabilization ... See more keywords
Studying the Mechanics of Membrane Permeabilization through Mechanoelectricity.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c19880
Abstract: In this research, real-time monitoring of lipid membrane disruption is made possible by exploiting the dynamic properties of model lipid bilayers formed at oil-water interfaces. This involves tracking an electrical signal generated through rhythmic membrane… read more here.
Keywords: mechanics; membrane permeabilization; membrane; studying mechanics ... See more keywords
Mechanisms of Photosensitized Lipid Oxidation and Membrane Permeabilization
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b03244
Abstract: Lipid oxidation encompasses chemical transformations affecting animals and plants in many ways, and light is one of the most common triggers of lipid oxidation in our habitat. Still, the molecular mechanisms and biological consequences of… read more here.
Keywords: oxidation; mechanisms photosensitized; lipid oxidation; membrane permeabilization ... See more keywords
Adaptation of a bacterial membrane permeabilization assay for quantitative evaluation of benzalkonium chloride as a membrane-disrupting agent.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00113d
Abstract: We describe the use of the ortho-nitrophenyl-β-galactoside (ONPG) assay developed by Lehrer et al. to which a new mathematical data treatment was applied. In this simplified assay, only one enzymatic assay is needed to provide… read more here.
Keywords: benzalkonium chloride; membrane permeabilization; membrane; permeabilization assay ... See more keywords
Dual stimuli-responsive cross-linked nanoassemblies from an amphiphilic mannose-6-phosphate based tri-block copolymer for lysosomal membrane permeabilization.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02110b
Abstract: Stimuli-responsive cross-linked nanocarriers that can induce lysosomal cell death (LCD) via lysosomal membrane permeabilization (LMP) represent a new class of delivery platforms and have attracted the attention of researchers in the biomedical field. The advantages… read more here.
Keywords: cross linked; membrane permeabilization; tri block; lysosomal membrane ... See more keywords
Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2171028
Abstract: Abstract The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reactions, and… read more here.
Keywords: cell; membrane; membrane permeabilization; lysosomal membrane ... See more keywords