Membrane‐Permeant, Bioactivatable Coumarin Derivatives for In‐Cell Labelling
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DOI: 10.1002/cbic.202100699
Abstract: The delivery of small molecule fluorophores with minimal compartmentalization is currently one of the most critical technical problems in intracellular labelling. Here we introduce sulfonated and phosphonated coumarin dyes, demonstrate rapid cell entry via a… read more here.
Keywords: derivatives cell; membrane permeant; cell labelling; coumarin derivatives ... See more keywords
Membrane Permeant Analogs for Independent Cellular Introduction of the Terpene Precursors Isopentenyl‐ and Dimethylallyl‐Pyrophosphate
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DOI: 10.1002/cbic.202200512
Abstract: Isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) are the central five‐carbon precursors to all terpenes. Despite their significance, exogenous, independent delivery of IPP and DMAPP to cells is impossible as the negatively charged pyrophosphate makes… read more here.
Keywords: dimethylallyl pyrophosphate; ipp dmapp; membrane permeant; pyrophosphate ... See more keywords
Monitoring the Cellular Metabolism of a Membrane-Permeant Photo-Caged Phosphatidylinositol 3,4,5-Trisphosphate Derivative.
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DOI: 10.1016/j.chemphyslip.2021.105124
Abstract: To deliver charged lipid derivatives to the cell interior, bioactivatable and photo-activatable protecting groups are frequently used. The intracellular metabolism of the protecting groups, as well as the lipid itself, are key factors that determine… read more here.
Keywords: metabolism; cellular metabolism; photo; protecting groups ... See more keywords