A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-07898-0
Abstract: CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major… read more here.
Keywords: escape channel; cell receptor; membrane phospholipids; cell ... See more keywords
Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf5122
Abstract: In marine systems, the availability of inorganic phosphate can limit primary production leading to bacterial and phytoplankton utilization of the plethora of organic forms available. Among these are phospholipids that form the lipid bilayer of… read more here.
Keywords: bacterial catabolism; links marine; membrane phospholipids; catabolism membrane ... See more keywords