Deep-Learning-Enhanced Diffusion Imaging Assay for Resolving Local-Density Effects on Membrane Receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04326
Abstract: G-protein-coupled receptor (GPCR) density at the cell surface is thought to regulate receptor function. Spatially resolved measurements of local-density effects on GPCRs are needed but technically limited by density heterogeneity and mobility of membrane receptors.… read more here.
Keywords: membrane receptors; diffusion; density; local density ... See more keywords
Recapitulating the Lateral Organization of Membrane Receptors at the Nanoscale.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00683
Abstract: Many cell membrane functions emerge from the lateral presentation of membrane receptors. The link between the nanoscale organization of the receptors and ligand binding remains, however, mostly unclear. In this work, we applied surface molecular… read more here.
Keywords: membrane receptors; organization membrane; lateral organization; membrane ... See more keywords
Short-time diffusive fluxes over membrane receptors yields the direction of a signalling source
Sign Up to like & getrecommendations! Published in 2023 at "Royal Society Open Science"
DOI: 10.1101/2023.03.30.534943
Abstract: An essential ability of many cell types is to detect stimuli in the form of shallow chemical gradients. Such cues may indicate the direction that new growth should occur, or the location of a mate.… read more here.
Keywords: membrane receptors; short time; diffusive fluxes; source ... See more keywords
The membrane receptors that appeared before their ligand: The different proposed scenarios
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231813
Abstract: The interactions between membrane receptors and their endogenous ligands are key interactions in organisms. Recently, we have shown that a high number of genes encoding human receptors appeared at the same moment as their ligand… read more here.
Keywords: membrane receptors; ligand different; different scenarios; receptors appeared ... See more keywords
Editorial: Recent Progress and Perspectives in Neurosteroid Research
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.951990
Abstract: The term "Neurosteroids" designates pregnenolone-derived bioactive compounds that are synthesized or catalyzedbyneural cells andact locally on the central orperipheral nervous systems.At themolecular level, the actions of neurosteroids are mainly mediated through membrane receptors i.e. via… read more here.
Keywords: recent progress; membrane receptors; progress perspectives; editorial recent ... See more keywords
Fluorolabeling of the PPTase-Related Chemical Tags: Comparative Study of Different Membrane Receptors and Different Fluorophores in the Labeling Reactions
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00195
Abstract: The set-up of an advanced imaging experiment requires a careful selection of suitable labeling strategies and fluorophores for the tagging of the molecules of interest. Here we provide an experimental workflow to allow evaluation of… read more here.
Keywords: pptase; chemical tags; labeling reactions; membrane receptors ... See more keywords