Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12891
Abstract: BACKGROUND Histone deacetylase 4 (HDAC4) is a stress-responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never… read more here.
Keywords: hdac4; membrane repair; muscular dystrophy; muscle ... See more keywords
Totally endoscopic tympanic membrane repair
Sign Up to like & getrecommendations! Published in 2021 at "HNO"
DOI: 10.1007/s00106-021-01052-x
Abstract: Transcanal totally endoscopic ear surgery (TEES) has become increasingly popular internationally; however, for surgeons trained with a two-handed microscope-guided approach, the potential challenges of adopting TEES can appear off-putting. This article outlines the pros and… read more here.
Keywords: endoscopic tympanic; totally endoscopic; membrane repair; membrane ... See more keywords
Single Molecule Imaging Reveals Dysferlin-Mediated Recruitment of Phosphatidylserine in Cell Membrane Repair
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.804
Abstract: Dysferlin (Dysf) has been implicated as a key protein for membrane repair in muscle cells, although its precise biological function is still unknown. Dysf is a transmembrane protein, and its rapid recruitment of Dysf to… read more here.
Keywords: membrane; cell membrane; single molecule; membrane repair ... See more keywords
ANO5 in membrane repair - Status: "It's complicated".
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102415
Abstract: ANO5/TMEM16E gene mutations are associated with myopathies. Two recent publications in the Journal of Cell Biology now both confirm that ANO5 deficiency results in defective plasma membrane repair and Ca2+ overload. But the big question… read more here.
Keywords: membrane repair; status complicated; biology; repair status ... See more keywords
An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread
Sign Up to like & getrecommendations! Published in 2018 at "Nature Microbiology"
DOI: 10.1038/s41564-018-0293-5
Abstract: Plasma membrane integrity is essential for the viability of eukaryotic cells. In response to bacterial pore-forming toxins, disrupted regions of the membrane are rapidly repaired. However, the pathways that mediate plasma membrane repair are unclear.… read more here.
Keywords: membrane repair; cell spread; cell cell; membrane ... See more keywords
Liprotides kill cancer cells by disrupting the plasma membrane
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15003-6
Abstract: HAMLET (human α-lactalbumin made lethal to tumour cells) is a complex of α-lactalbumin (aLA) and oleic acid (OA) which kills transformed cells, while leaving fully differentiated cells largely unaffected. Other protein-lipid complexes show similar anti-cancer… read more here.
Keywords: liprotides kill; membrane repair; cancer; membrane ... See more keywords
Janus polymer-grafted nanoparticles mimicking membrane repair proteins for the prevention of lipid membrane rupture.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d3nr00395g
Abstract: Plasma membrane rupture often leads to cell damage, especially when there is a lack of membrane repair proteins near the wounds due to genetic mutations in organisms. To efficiently promote the repair of the injured… read more here.
Keywords: membrane repair; repair proteins; polymer; membrane ... See more keywords
Mitochondria for plasma membrane repair
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.357.6355.1011-m
Abstract: Cell Biology Mechanical strain on cells can cause damage to the plasma membrane that must be repaired before extracellular Ca2+ influx reaches levels that trigger cell death. Horn et al. found that mitochondria mediated the… read more here.
Keywords: mitochondria plasma; membrane repair; biology; membrane ... See more keywords
ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abl3855
Abstract: Cytotoxic T lymphocytes (CTLs) and natural killer cells kill virus-infected and tumor cells through the polarized release of perforin and granzymes. Perforin is a pore-forming toxin that creates a lesion in the plasma membrane of… read more here.
Keywords: derived cells; membrane repair; membrane; target ... See more keywords
Neuronal Membrane Repair Defect as a Contributor to Amyloid Beta Pathogenesis in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731327
Abstract: Alzheimer’s Disease (AD) is a common neurodegenerative disease that displays two hallmark protein accumulations in the brain – extracellular amyloid beta (Aβ) and intracellular hyperphosphorylated tau. Aβ has been shown to directly penetrate the neuronal… read more here.
Keywords: membrane repair; disease; physiology; membrane ... See more keywords
A conserved annexin A6–mediated membrane repair mechanism in muscle, heart, and nerve
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158107
Abstract: Membrane instability and disruption underlie myriad acute and chronic disorders. Anxa6 encodes the membrane-associated protein annexin A6 and was identified as a genetic modifier of muscle repair and muscular dystrophy. To evaluate annexin A6’s role… read more here.
Keywords: membrane repair; annexin mediated; annexin; muscle ... See more keywords