Helical foldamers replicating membrane-spanning gramicidin a with pH responsiveness and ultrafast potassium permeability
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc01362c
Abstract: Structural simulation of natural ion channels remains a challenging topic. To fabricate artificial ion channels structurally resembling natural gramicidin A (gA), we prepared a type of precise hollow helical molecular channel by means of a… read more here.
Keywords: transport; ion transport; membrane spanning; ion ... See more keywords
Dual membrane-spanning anti-sigma factors regulate vesiculation in Bacteroides thetaiotaomicron
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2321910121
Abstract: Significance Bacteroidota are key members of the human gut microbiota that can modulate the enteric environment by producing vesicles. Bacterial vesiculation is a poorly understood process. Here, we developed a high-throughput screen to identify genes… read more here.
Keywords: vesiculation; dual membrane; vesiculation bacteroides; membrane spanning ... See more keywords
Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-03-0144
Abstract: Previous studies indicated that IRE1α responds to membrane aberrancy via its transmembrane domain (TMD); however, little is known about the TMD features involved. Use of CRISPR/Cas9-mediated gene editing shows that generic membrane-spanning features of the… read more here.
Keywords: spanning features; generic membrane; membrane spanning; membrane aberrancy ... See more keywords
Changes in the Distribution of Membrane Lipids during Growth of Thermotoga maritima at Different Temperatures: Indications for the Potential Mechanism of Biosynthesis of Ether-Bound Diabolic Acid (Membrane-Spanning) Lipids
Sign Up to like & getrecommendations! Published in 2021 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01763-21
Abstract: Membrane-spanning lipids are unique compounds found in most archaeal membranes, but they are also present in specific bacterial groups like the Thermotogales. The synthesis and physiological role of membrane-spanning lipids in bacteria represent an evolutionary… read more here.
Keywords: growth; diabolic acids; membrane; membrane spanning ... See more keywords
Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232416225
Abstract: ABC transporters are large membrane proteins sharing a complex architecture, which comprises two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). These domains are susceptible to mutations affecting their folding and assembly. In the CFTR… read more here.
Keywords: membrane spanning; spanning domains; cftr; cftr membrane ... See more keywords
A Surfactant Enables Efficient Membrane Spanning by Non-Aggregating DNA-Based Ion Channels
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27020578
Abstract: DNA nanotechnology makes use of hydrophobically modified constructs to create synthetic membrane protein mimics. However, nucleic acid structures exhibit poor insertion efficiency, leading to a low activity of membrane-spanning DNA protein mimics. It is suggested… read more here.
Keywords: membrane spanning; dna; non aggregating; membrane ... See more keywords