Photocontrolled Spatiotemporal Delivery of DNA Immunomodulators for Enhancing Membrane-Targeted Tumor Photodynamic Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c12774
Abstract: Immunotherapy is emerging as a paradigm-shifting modality for treatment cancer. However, systemic administration of immunomodulators is usually accompanied by extra-tumor toxicity and adverse immune effects. Precise delivery of immunomodulators with a highly controllable system may… read more here.
Keywords: dna; membrane targeted; immunotherapy; dna immunomodulators ... See more keywords
Enzyme-Driven Membrane-Targeted Chimeric Peptide for Enhanced Tumor Photodynamic-Immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b04315
Abstract: Here, a protein farnesyltransferase (PFTase)-driven plasma membrane (PM)-targeted chimeric peptide PpIX-C6-PEG8-KKKKKKSKTKC-OMe (PCPK) was designed for PM-targeted photodynamic therapy (PM-PDT) and enhanced immunotherapy via tumor cell PM damage and fast release of damage-associated molecular patterns (DAMPs).… read more here.
Keywords: chimeric peptide; targeted chimeric; membrane targeted; membrane ... See more keywords
Cooperative tumour cell membrane targeted phototherapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15880
Abstract: The targeted delivery of therapeutics using antibodies or nanomaterials has improved the precision and safety of cancer therapy. However, the paucity and heterogeneity of identified molecular targets within tumours have resulted in poor and uneven… read more here.
Keywords: tumour cell; cell; cell membrane; membrane targeted ... See more keywords