A dual-usage near-infrared (NIR) cell membrane targeting chimeric peptide for cancer cell membrane imaging and photothermal ablation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-04546-1
Abstract: Due to the low background and deep tissue penetration of near-infrared light, near-infrared fluorescence (NIRF) probes have received much attention in recent years. Cell membrane targeting probes can be used in in vitro and in… read more here.
Keywords: chimeric peptide; cell membrane; near infrared; membrane targeting ... See more keywords
Basolateral cholesterol depletion alters Aquaporin-2 post-translational modifications and disrupts apical plasma membrane targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.002
Abstract: Apical plasma membrane accumulation of the water channel Aquaporin-2 (AQP2) in kidney collecting duct principal cells is critical for body water homeostasis. Posttranslational modification (PTM) of AQP2 is important for regulating AQP2 trafficking. The aim… read more here.
Keywords: cholesterol; membrane targeting; apical plasma; membrane ... See more keywords
CD320 expression and apical membrane targeting in renal and intestinal epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.12.158
Abstract: Vitamin B12 is an essential nutrient acquired via dietary intake. Receptor-mediated endocytosis is a key mechanism in vitamin B12 absorption, cellular uptake, and reabsorption. CD320 is a type I transmembrane protein responsible for cellular uptake… read more here.
Keywords: cd320; apical membrane; vitamin b12; membrane targeting ... See more keywords
Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.04.017
Abstract: Much of our knowledge on the function of proteins is deduced from their mature, folded states. However, it is unknown whether partially synthesized nascent protein segments can execute biological functions during translation and whether their… read more here.
Keywords: signal recognition; membrane targeting; recognition particle; particle receptor ... See more keywords
Co-translational membrane targeting and holo-translocon docking of ribosomes translating the SRP receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2022.167459
Abstract: Many integral membrane proteins are produced by translocon-associated ribosomes. The assembly of ribosomes translating membrane proteins on the translocons is mediated by a conserved system, composed of the signal recognition particle and its receptor (FtsY… read more here.
Keywords: ribosomes translating; membrane targeting; translational membrane; membrane ... See more keywords
Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01793
Abstract: Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and with limited clinically available antibiotics, it is urgent to develop new antimicrobials to combat these MDR bacteria. Here, a class of novel amphiphilic xanthohumol derivatives… read more here.
Keywords: membrane targeting; methicillin resistant; amphiphilic xanthohumol; staphylococcus aureus ... See more keywords
De novo design of a reversible phosphorylation-dependent switch for membrane targeting
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21622-5
Abstract: Modules that switch protein-protein interactions on and off are essential to develop synthetic biology; for example, to construct orthogonal signaling pathways, to control artificial protein structures dynamically, and for protein localization in cells or protocells.… read more here.
Keywords: switch; membrane targeting; reversible phosphorylation; novo design ... See more keywords
Two-photon excitable membrane targeting polyphenolic carbon dots for long-term imaging and pH-responsive chemotherapeutic drug delivery for synergistic tumor therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01832a
Abstract: Long-term dynamic tracking of cells with theranostic properties remains challenging due to the difficulty in preparing and delivering drugs by probes. Herein, we developed highly fluorescent one- and two-photon (OP and TP) excitable polyphenolic carbon… read more here.
Keywords: tumor; drug delivery; membrane targeting; tumor therapy ... See more keywords
A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc01260j
Abstract: The exploration of cellular organelle-specific anchoring photosensitizers with both prominent fluorescence imaging behavior and extraordinary reactive oxygen species (ROS) production capability is highly in demand but remains a severe challenge for effective cancer theranostics involving… read more here.
Keywords: cell membrane; membrane targeting; aie photosensitizer; cancer ... See more keywords
Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt01001e
Abstract: A ruthenium complex [Ru(phen)2(phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was designed and synthesized; positively charged Ru-C14 could target bacteria via electrostatic interactions and showed high binding effectiveness to cell membranes. In addition, Ru-C14 could act… read more here.
Keywords: c14; antibacterial activity; membrane targeting; spectrum antibacterial ... See more keywords
Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200884
Abstract: Defensins are a class of host defence peptides (HDPs) that often harbour antimicrobial and anticancer activities, making them attractive candidates as novel therapeutics. In comparison with current antimicrobial and cancer treatments, defensins uniquely target specific… read more here.
Keywords: antimicrobial anticancer; defensin lipid; membrane targeting; lipid interactions ... See more keywords