Membrane tension buffering by caveolae: a role in cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09899-2
Abstract: Caveolae are bulb-like invaginations made up of two essential structural proteins, caveolin-1 and cavins, which are abundantly present at the plasma membrane of vertebrate cells. Since their discovery more than 60 years ago, the function of… read more here.
Keywords: caveolae; membrane tension; caveolae role; role cancer ... See more keywords
Effects of Membrane Tension on Snare-Mediated Single Fusion Pores
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2153
Abstract: Fast and temporally controlled release is imperative for neurotransmitter release via evoked synaptic vesicle exocytosis. This process is driven by the interaction between vesicle v-SNAREs with target t-SNAREs on the plasma membrane. The initial, nanometer-sized… read more here.
Keywords: membrane tension; snare mediated; fusion; fusion pores ... See more keywords
Membrane Tension and the Charge State of Cells
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.203
Abstract: Many of the ways that cells talk and listen to the external world center on the presence of proteins on the cell surface. Indeed, the cell membrane is an amazingly diverse lipid environment, riddled in… read more here.
Keywords: tension charge; membrane tension; charge state; state cells ... See more keywords
Cholesterol Depletion by MβCD Enhances Cell Membrane Tension and Its Variations-Reducing Integrity
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.03.016
Abstract: Cholesterol depletion by methyl-β-cyclodextrin (MβCD) remodels the plasma membrane’s mechanics in cells and its interactions with the underlying cytoskeleton, whereas in red blood cells, it is also known to cause lysis. Currently it’s unclear if… read more here.
Keywords: tension; membrane tension; cholesterol depletion;
Durotaxis Index of 3T3 Fibroblast Cells Scales with Stiff-to-Soft Membrane Tension Polarity.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.07.039
Abstract: Cell durotaxis is an essential process in tissue development. Although the role of cytoskeleton in cell durotaxis has been widely studied, whether cell volume and membrane tension are implicated in cell durotaxis remains unclear. By… read more here.
Keywords: cell durotaxis; membrane tension; cell; volume ... See more keywords
Endocytosis and Exocytosis Protect Cells against Severe Membrane Tension Variations.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.11.019
Abstract: The ability of cells to regulate their shape and volume is critical for many cell functions. How endocytosis and exocytosis, as important ways of membrane trafficking, affect cellular volume regulation is still unclear. Here, we… read more here.
Keywords: membrane tension; exocytosis; volume; endocytosis exocytosis ... See more keywords
Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer’s Disease Peptide Aβ(1-42)
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.0c00053
Abstract: Intraneuronal accumulation of amyloid-β (Aβ) is an early pathological signum of Alzheimer’s disease, and compartments of the endolysosomal system have been implicated in both seeding and cell–cell propagation of Aβ aggregation. We have studied how… read more here.
Keywords: alzheimer disease; membrane tension; cell; rho gtpases ... See more keywords
Mechanosensitive Channel-Based Optical Membrane Tension Reporter.
Sign Up to like & getrecommendations! Published in 2023 at "ACS sensors"
DOI: 10.1021/acssensors.2c01921
Abstract: Plasma membrane tension functions as a global physical organizer of cellular activities. Technical limitations of current membrane tension measurement techniques have hampered in-depth investigation of cellular membrane biophysics and the role of plasma membrane tension… read more here.
Keywords: optical membrane; tension reporter; membrane tension; mechanosensitive channel ... See more keywords
MCAs in Arabidopsis are Ca2+-permeable mechanosensitive channels inherently sensitive to membrane tension.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26363-z
Abstract: Mechanosensitive (MS) ion channels respond to mechanical stress and convert it into intracellular electric and ionic signals. Five MS channel families have been identified in plants, including the Mid1-Complementing Activity (MCA) channel; however, its activation… read more here.
Keywords: ca2 permeable; membrane tension; channel; ca2 ... See more keywords
HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cells
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05208j
Abstract: HydroFlippers are introduced as the first fluorescent membrane tension probes that report simultaneously on membrane compression and hydration. The probe design is centered around a sensing cycle that couples the mechanical planarization of twisted push–pull… read more here.
Keywords: membrane tension; living cells; tension; membrane ... See more keywords
Membrane tension controls the phase equilibrium in fusogenic liposomes
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra04019k
Abstract: Fusogenic liposomes have been widely used for molecule delivery to cell membranes and cell interior. However, their physicochemical state is still little understood. We tested mechanical material behavior by micropipette aspiration of giant vesicles from… read more here.
Keywords: controls phase; fusogenic liposomes; phase equilibrium; membrane tension ... See more keywords