20+ Years and no End in Sight: Histidine-Rich Designer Peptides with pH-Dependent Membrane Topology and with Multifacet Biomedical Potential
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.165
Abstract: The synthetic LAH4 peptides were designed to investigate the interactions that determine the membrane topology of helical peptides (1). Their core consists of alanines, leucine and four histidines arranged to form an amphipathic helix, as… read more here.
Keywords: membrane topology; lah4 peptides; years end; topology ... See more keywords
Amino acid composition analysis of human secondary transport proteins and implications for reliable membrane topology prediction
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1167622
Abstract: Secondary transporters in humans are a large group of proteins that transport a wide range of ions, metals, organic and inorganic solutes involved in energy transduction, control of membrane potential and osmotic balance, metabolic processes… read more here.
Keywords: amino acid; secondary transport; transport proteins; membrane topology ... See more keywords
Escherichia coli and Pseudomonas aeruginosa lipopolysaccharide O‐antigen ligases share similar membrane topology and biochemical properties
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.14085
Abstract: WaaL is an inner membrane glycosyltransferase that catalyzes the transfer of O‐antigen polysaccharide from its lipid‐linked intermediate to a terminal sugar of the lipid A‐core oligosaccharide, a conserved step in lipopolysaccharide biosynthesis. Ligation occurs at… read more here.
Keywords: pseudomonas aeruginosa; escherichia coli; membrane topology; topology ... See more keywords