New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2627
Abstract: Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent advances in research on membrane transporters that are… read more here.
Keywords: discovery development; drug discovery; transporter; membrane transporters ... See more keywords
A mathematical modeling toolbox for ion channels and transporters across cell membranes
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Heat and Mass Transfer"
DOI: 10.1016/j.ijheatmasstransfer.2021.121423
Abstract: Abstract Mathematical modeling of membrane transporters and ion channels helps researchers obtain a thorough understanding of the complex regulation process between membrane transporters, estimate the changes and uncertainties of their mechanisms, and study how disorders… read more here.
Keywords: mathematical modeling; across cell; ion channels; ion ... See more keywords
A thermodynamic framework for modelling membrane transporters.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.09.034
Abstract: Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell membranes. Like all physical systems, the behaviour of membrane transporters is constrained by the laws of thermodynamics. However,… read more here.
Keywords: membrane transporters; framework modelling; modelling membrane; thermodynamic framework ... See more keywords
Adenosine and preeclampsia.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2016.12.003
Abstract: Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate… read more here.
Keywords: membrane transporters; adenosine preeclampsia; preeclampsia; adenosine receptors ... See more keywords
Optimized Data Set and Feature Construction for Substrate Prediction of Membrane Transporters
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00850
Abstract: α-Helical transmembrane proteins termed membrane transporters mediate the passage of small hydrophilic substrate molecules across biological lipid bilayer membranes. Annotating the specific substrates of the dozens to hundreds of individual transporters of an organism is… read more here.
Keywords: set feature; substrate; membrane transporters; optimized data ... See more keywords
Heterologous expression of the yeast Tpo1p or Pdr5p membrane transporters in Arabidopsis confers plant xenobiotic tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04534-7
Abstract: Soil contamination is a major hindrance for plant growth and development. The lack of effective strategies to remove chemicals released into the environment has raised the need to increase plant resilience to soil pollutants. Here,… read more here.
Keywords: membrane transporters; plant; tpo1p pdr5p; tolerance ... See more keywords
The roles of membrane transporters in arsenic uptake, translocation and detoxification in plants
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Environmental Science and Technology"
DOI: 10.1080/10643389.2020.1795053
Abstract: Abstract Arsenic (As) is one of the most toxic environmental contaminants that is ubiquitously distributed in the environment. Millions of people worldwide suffer from As poisoning due to As exposure from drinking water and dietary… read more here.
Keywords: membrane transporters; accumulation; uptake translocation; detoxification ... See more keywords
A Chemogenomic Toolkit to Evaluate the “Ins and Outs” of Yeast Plasma Membrane Transporters
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00955-22
Abstract: Over the years, there has been a lot of emphasis on the development of high-throughput platforms that help identify transporters of drugs and xenobiotics. However, major hinderances in these approaches include substrate promiscuity and functional… read more here.
Keywords: chemogenomic toolkit; toolkit evaluate; high throughput; membrane ... See more keywords
P98 Semi-quantification and localization of membrane transporters in paediatric kidney tissue
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-esdppp.136
Abstract: Background The kidney has a critical role in disposition, efficacy and toxicity of drugs and xenobiotics. Developmental changes of renal membrane transporters have the potential to explain population variability in paediatric pharmacokinetics and -dynamics of… read more here.
Keywords: membrane transporters; age; paediatric kidney; localization ... See more keywords
Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263692
Abstract: Pharmaceutical excipients are the basic materials and important components of pharmaceutical preparations, and play an important role in improving the efficacy of drugs and reducing adverse reactions. Therefore, selecting suitable excipients for dosage form is… read more here.
Keywords: cremophor; effect; influence; membrane transporters ... See more keywords
The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052443
Abstract: The choroid plexuses (CPs), located in the brain ventricles, form an interface between the blood and the cerebrospinal fluid named the blood-cerebrospinal barrier, which, by the presence of tight junctions, detoxification enzymes, and membrane transporters,… read more here.
Keywords: blood cerebrospinal; circadian way; abcc4; intact male ... See more keywords