Membraneless organelles: a smart design for metabolic control
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13264
Abstract: While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in the cell by avoiding the mixture of their components with the surroundings. Actually, liquid–liquid phase separation provides a simple… read more here.
Keywords: membraneless organelles; smart design; article; organelles smart ... See more keywords
Multifaceted Cargo Recruitment and Release from Artificial Membraneless Organelles.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201721
Abstract: Liquid-liquid phase separation (LLPS) drives membraneless organelles (MLOs) formation for organizing biomolecules. Artificial MLOs (AMLOs) have been constructed mostly via the LLPS of engineered proteins capable of regulating limited types of biomolecules. Here, leveraging a… read more here.
Keywords: membraneless organelles; recruitment release; cargo recruitment; recruitment ... See more keywords
RNA-seeded membraneless bodies: Role of tandemly repeated RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2020.12.007
Abstract: Membraneless organelles (bodies, granules, etc.) are spatially distinct sub-nuclear and cytoplasmic foci involved in all the processes in a living cell, such as development, cell death, carcinogenesis, proliferation, and differentiation. Today the list of the… read more here.
Keywords: role; membraneless; membraneless organelles; rna seeded ... See more keywords
Biomolecular condensates in cell biology and virology: phase-separated membraneless organelles (MLOs).
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113691
Abstract: Membraneless organelles (MLOs) in the cytoplasm and nucleus in the form of 2D and 3D phase-separated biomolecular condensates are increasingly viewed as critical in regulating diverse cellular functions. These functions include cell signaling, immune synapse… read more here.
Keywords: membraneless organelles; virology; biology; phase separated ... See more keywords
Quality Control of Membraneless Organelles.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.05.013
Abstract: The formation of membraneless organelles (MLOs) by phase separation has emerged as a new way of organizing the cytoplasm and nucleoplasm of cells. Examples of MLOs forming via phase separation are nucleoli in the nucleus… read more here.
Keywords: membraneless organelles; phase; quality control;
Chromatin-Associated Membraneless Organelles in Regulation of Cellular Differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2020.10.011
Abstract: Membrane-free intracellular biocondensates are enclosures of proteins and nucleic acids that form by phase separation. Extensive ensembles of nuclear “membraneless organelles” indicate their involvement in genome regulation. Indeed, nuclear bodies have been linked to regulation… read more here.
Keywords: associated membraneless; membraneless organelles; membraneless; differentiation ... See more keywords
Physiological, Pathological, and Targetable Membraneless Organelles in Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.08.005
Abstract: Neurons require unique subcellular compartmentalization to function efficiently. Formed from proteins and RNAs through liquid-liquid phase separation, membraneless organelles (MLOs) have emerged as one way in which cells form distinct, specialized compartments in the absence… read more here.
Keywords: membraneless organelles; physiological pathological; targetable membraneless; membraneless ... See more keywords
Phase Separation Behavior of Supercharged Proteins and Polyelectrolytes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00990
Abstract: Membraneless organelles, like membrane-bound organelles, are essential to cell homeostasis and provide discrete cellular subcompartments. Unlike classical organelles, membraneless organelles possess no physical barrier but rather arise by phase separation of the organelle components from… read more here.
Keywords: membraneless organelles; phase separation; phase; behavior ... See more keywords
Controllable protein phase separation and modular recruitment to form responsive membraneless organelles
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05403-1
Abstract: Many intrinsically disordered proteins self-assemble into liquid droplets that function as membraneless organelles. Because of their biological importance and ability to colocalize molecules at high concentrations, these protein compartments represent a compelling target for bio-inspired… read more here.
Keywords: membraneless organelles; phase separation; membraneless; recruitment ... See more keywords
Kinase-controlled phase transition of membraneless organelles in mitosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0279-8
Abstract: Liquid–liquid phase separation has been shown to underlie the formation and disassembly of membraneless organelles in cells, but the cellular mechanisms that control this phenomenon are poorly understood. A prominent example of regulated and reversible… read more here.
Keywords: membraneless organelles; mitosis; liquid; kinase ... See more keywords
Enzyme-active liquid coacervate microdroplets as artificial membraneless organelles for intracellular ROS scavenging.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00713d
Abstract: Artificial organelles are microcompartments capable of performing catalytic reactions in living cells to replace absent or lost cellular functions. Coacervate microdroplets, formed via liquid-liquid phase separation, have been developed as membraneless organelles that mimic the… read more here.
Keywords: membraneless organelles; artificial membraneless; liquid; living cells ... See more keywords