An Aβ42 double mutant inhibits Aβ42-induced plasma and mitochondrial membrane disruption in artificial membranes, isolated organs and intact cells.
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DOI: 10.1021/acschemneuro.9b00638
Abstract: Destabilization of plasma and inner mitochondrial membranes by extra- and intracellular amyloid β peptide (Aβ42) aggregates may lead to dysregulated calcium flux through the plasma membrane, mitochondrial-mediated apoptosis and neuronal cell death in patients with… read more here.
Keywords: membranes isolated; artificial membranes; plasma mitochondrial; mitochondrial membrane ... See more keywords