Segmental membranous nephropathy
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DOI: 10.1007/s10157-021-02056-1
Abstract: Most cases of membranous nephropathy (MGN) present with global and diffuse distribution of subepithelial deposits. However, segmental MGN, in which there is focal or diffuse segmental subepithelial deposits, are occasionally encountered. The clinical and pathologic… read more here.
Keywords: nephrology; segmental membranous; membranous nephropathy; segmental mgn ... See more keywords
THSD7A as a marker for paraneoplastic membranous nephropathy
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DOI: 10.1007/s11255-018-02068-z
Abstract: The phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are the two major autoantigens in primary membranous nephropathy (MN) [1, 2]. In particular, the THSD7A-associated MN may have a unique relationship with… read more here.
Keywords: antibody; pathology; malignancy; membranous nephropathy ... See more keywords
Treatment of primary membranous nephropathy: where are we now?
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DOI: 10.1007/s40620-017-0427-5
Abstract: In the last 10 years, basic science and clinical research have made important contributions to the understanding and management of primary membranous nephropathy (MN). The identification of antibodies directed against the M-type phospholipase A2 receptor (PLA2R)… read more here.
Keywords: nephrology; treatment primary; treatment; membranous nephropathy ... See more keywords
Recurrent venous thromboembolism in primary membranous nephropathy despite direct Xa inhibitor therapy
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DOI: 10.1007/s40620-018-0552-9
Abstract: Clinically apparent venous thromboembolism (VTE) occurs in approximately 7% of patients with membranous nephropathy. Hypoalbuminemia at diagnosis is an independent risk factor for VTE, and risk increases significantly as albumin falls. Optimal prophylactic and treatment… read more here.
Keywords: recurrent venous; venous thromboembolism; membranous nephropathy; inhibitor ... See more keywords
Identical twins with idiopathic membranous nephropathy
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DOI: 10.1007/s40620-020-00770-9
Abstract: The pathogenesis of idiopathic membranous nephropathy is associated with autoantibodies, most often against the phospholipase A2 receptor (PLA2R) and with genetic factors, especially those involving human leukocyte antigen (HLA) genes. Idiopathic membranous nephropathy is not… read more here.
Keywords: nephrology; twins idiopathic; hla; membranous nephropathy ... See more keywords
Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy: A systematic review and meta-analysis of 21 clinical trials.
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DOI: 10.1016/j.autrev.2016.12.005
Abstract: OBJECTIVE To compare the efficacy and safety of calcineurin inhibitors (CNIs) with cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN). METHODS A literature search was carried out using PubMed, EMBASE, Cochrane Central Register… read more here.
Keywords: calcineurin inhibitors; tac ctx; efficacy safety; ctx ... See more keywords
Comparison of 3 anti-PLA2R inmmunoassaysfor the diagnosis of idiopathic membranous nephropathy in an european population. A pilot study.
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DOI: 10.1016/j.clim.2021.108729
Abstract: Membranous nephropathy (MN) is one of the most frequent causes of nephrotic syndrome. Renal biopsy is nowadays the gold standard for the diagnosis of MN. The presence of circulating PLA2R antibody is a very specific… read more here.
Keywords: membranous nephropathy; anti pla2r; pilot study; diagnosis ... See more keywords
Altered Th17/Treg ratio as a possible mechanism in pathogenesis of idiopathic membranous nephropathy.
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DOI: 10.1016/j.cyto.2021.155452
Abstract: Idiopathic membranous nephropathy (IMN) as a single organ autoimmune disease is a main cause of nephrotic syndrome in adults which is determined through autoantibodies to podocytes proteins. Th17/regulatory T (Treg) balance has emerged as a… read more here.
Keywords: th17 treg; pathogenesis; altered th17; membranous nephropathy ... See more keywords
CD19 Targeted Low-Dose Rituximab Is Effective in the Management of Refractory Phospholipase A2 Receptor Antibody-Associated Membranous Nephropathy
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DOI: 10.1016/j.ekir.2016.08.019
Abstract: To the Editor: Varied dosing regimens of rituximab (RTX) have been successfully used in the management of primary membranous nephropathy (PMN). An ideal RTX dose and the long-term adverse effect of a larger cumulative dose… read more here.
Keywords: cd19; low dose; range; management ... See more keywords
Membranous Nephropathy in a Patient With Common Variable Immune Deficiency
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DOI: 10.1016/j.ekir.2017.12.002
Abstract: Byum Hee Kil, Teena Zachariah, S. Ali Husain, Jordan Nestor, Renu Regunathan-Shenk, Glen S. Markowitz and Andrew S. Bomback Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New… read more here.
Keywords: patient common; pathology; common variable; nephropathy patient ... See more keywords
Rituximab in Patients With Phospholipase A2 Receptor–Associated Membranous Nephropathy and Severe CKD
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DOI: 10.1016/j.ekir.2019.12.006
Abstract: Introduction Patients with phospholipase A2 receptor (PLA2R)–associated membranous nephropathy and stage 4 or 5 chronic kidney disease are at high risk of end-stage kidney disease. In recent years, rituximab (RTX) emerged as a safe and… read more here.
Keywords: associated membranous; patients phospholipase; treatment; membranous nephropathy ... See more keywords