Compromised long‐lived memory CD8+ T cells are associated with reduced IL‐7 responsiveness in HIV‐infected immunological nonresponders
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149203
Abstract: Immune deficiency is one of the hallmarks of HIV infection and a major cause of adverse outcomes in people living with HIV (PLWH). Long‐lived memory CD8+ T cells (LLMCs) are essential executors of long‐term protective… read more here.
Keywords: lived memory; hiv; memory cd8; memory ... See more keywords
Memory CD8+ T cells upregulate glycolysis and effector functions under limiting oxygen conditions
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249918
Abstract: Memory CD8+ T cells are indispensable for maintaining long‐term immunity against intracellular pathogens and tumors. Despite their presence at oxygen‐deprived infected tissue sites or in tumors, the impact of local oxygen pressure on memory CD8+… read more here.
Keywords: oxygen pressure; memory cd8; cd8 cells; cd8 ... See more keywords
Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.10.111
Abstract: Summary The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses. Marginal zone macrophages (MZMs)… read more here.
Keywords: marginal zone; zone; spleen marginal; cd8 cells ... See more keywords
Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.10.026
Abstract: &NA; The generation of tissue resident memory (TRM) cells at the body surfaces to provide a front line defence against invading pathogens represents an important goal in vaccine development for a wide variety of pathogens.… read more here.
Keywords: cd8; cd8 cells; memory cd8; vaccine ... See more keywords
Control of memory CD8+ T cell longevity and effector functions by IL-15.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.11.011
Abstract: IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival… read more here.
Keywords: memory cd8; cell; memory; effector functions ... See more keywords
Unsupervised learning techniques reveal heterogeneity in memory CD8+ T cell differentiation following acute, chronic and latent viral infections.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.06.018
Abstract: CD8+ T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8+ T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive… read more here.
Keywords: cd8; cd8 cells; infection; memory cd8 ... See more keywords
Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0414-z
Abstract: To expand the breadth and extent of current multiple myeloma (MM)-specific immunotherapy, we have identified various antigens on CD138+ tumor cells from newly diagnosed MM patients (n = 616) and confirmed B-cell maturation antigen (BCMA) as a… read more here.
Keywords: bcma specific; myeloma; bcma; memory cd8 ... See more keywords
Influenza- and MCMV-induced memory CD8 T cells control respiratory vaccinia virus infection despite residence in distinct anatomical niches
Sign Up to like & getrecommendations! Published in 2021 at "Mucosal Immunology"
DOI: 10.1038/s41385-020-00373-4
Abstract: Induction of memory CD8 T cells residing in peripheral tissues is of interest for T cell-based vaccines as these cells are located at mucosal and barrier sites and can immediately exert effector functions, thus providing… read more here.
Keywords: cd8 cells; memory cd8; induced memory; virus ... See more keywords
Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1438800
Abstract: ABSTRACT Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short serum half-life and high dose-related toxicities limit its clinical efficacy. Here, we constructed heterodimeric immunoglobulin Fc-fused mouse IL12 (mIL12)… read more here.
Keywords: il12; cd8 cells; mil12; memory cd8 ... See more keywords
Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1442163
Abstract: ABSTRACT Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8+ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens.… read more here.
Keywords: memory cd8; vaccination; vaccination induced; trm ... See more keywords
Similar but different: virtual memory CD8 T cells as a memory‐like cell population
Sign Up to like & getrecommendations! Published in 2019 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12277
Abstract: Immunological memory is a phenomenon where the immune system can respond more rapidly to pathogens and immunological challenges that it has previously encountered. It is defined by several key hallmarks. After an initial encounter, immune… read more here.
Keywords: cell population; memory cd8; virtual memory; cell ... See more keywords