Chromatin priming elements establish immunological memory in T cells without activating transcription
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600184
Abstract: We have identified a simple epigenetic mechanism underlying the establishment and maintenance of immunological memory in T cells. By studying the transcriptional regulation of inducible genes we found that a single cycle of activation of… read more here.
Keywords: transcription; immunological memory; memory cells; chromatin priming ... See more keywords
Intestinal helminth infection induces highly functional resident memory CD4+ T cells in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646575
Abstract: Immunity to intestinal nematodes requires CD4⁺ Th2‐cell responses, including IL‐4 and IL‐13 production. Chronic infection with intestinal nematodes leads to downregulation of these responses, and few functional T helper (Th) 2 cells are detected in… read more here.
Keywords: highly functional; memory cells; infection; intestinal helminth ... See more keywords
Intestinal CD8+ tissue‐resident memory T cells: From generation to function
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149759
Abstract: Tissue‐resident memory T cells (Trm), and particularly the CD8+ subset, have been shown to play a pivotal role in protection against infections and tumors. Studies in animal models and human tissues have highlighted that, while… read more here.
Keywords: resident memory; tissue resident; memory cells; intestinal cd8 ... See more keywords
Regulatory T‐cell‐derived interleukin‐15 shapes cytotoxic T cell memory
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250238
Abstract: It is well known that regulatory T‐cells (Tregs) are required to prevent autoimmunity, but they may also have some less‐well understood immune‐stimulatory effects. In particular, in CD8+ T‐cell responses Tregs select high‐affinity clones upon priming… read more here.
Keywords: cell; regulatory cell; cell memory; memory ... See more keywords
Dysregulation of memory B cells and circulating T follicular helper cells is a predictor of poor immune recovery in HIV‐infected patients on antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28559
Abstract: T follicular helper (Tfh) cells and their interactions with B cells within the germinal center play extensive roles in human immunodeficiency virus (HIV) pathology. However, their association with immune reconstitution during antiretroviral therapy (ART) is… read more here.
Keywords: cell; hiv; memory cells; immune recovery ... See more keywords
Differentiation of Diverse Progenies of Memory T Cells from Naïve CD8+ T Cell Precursors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6548-9_8
Abstract: Following recognition of the cognate antigen, naïve T cells differentiate in a diverse progeny of memory T cells which differ at the phenotypic, gene expression and metabolic level. These molecular differences are at the basis… read more here.
Keywords: cd8 cell; cell precursors; memory cells; differentiation diverse ... See more keywords
In utero development of memory T cells
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0650-0
Abstract: Pathogen-specific immune memory develops subsequent to primary exposure to antigen, mainly in the context of infection or vaccination to provide protection. Although a safe fetal life requires a tolerogenic environment in order to circumvent unnecessary… read more here.
Keywords: development memory; utero development; memory cells; infection ... See more keywords
Association between memory B-cells and clinical and immunological features of primary Sjögren’s syndrome and Sicca patients
Sign Up to like & getrecommendations! Published in 2018 at "Rheumatology International"
DOI: 10.1007/s00296-018-4018-0
Abstract: B-cells play a pivotal role in primary Sjögren’s syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls,… read more here.
Keywords: gren syndrome; sicca patients; memory cells; pss ... See more keywords
Memory T Cells in Type 1 Diabetes: the Devil is in the Detail
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DOI: 10.1007/s11892-017-0889-9
Abstract: Purpose of ReviewTherapies that target beta-cell antigen-specific T cells subsets have not been as successful in patients with type 1 diabetes as in mice. This might be explained by complexities in the repertoire of beta-cell… read more here.
Keywords: cells type; diabetes devil; memory cells; type diabetes ... See more keywords
Fingolimod Immune Effects Beyond Its Sequestration Ability
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DOI: 10.1007/s40120-019-00162-7
Abstract: Fingolimod is the first orally administered drug approved for the treatment of relapsing–remitting multiple sclerosis (MS). This drug, modulating sphingosine receptors, regulates the trafficking of lymphocytes between primary and secondary lymphoid organs, trapping naïve T… read more here.
Keywords: beyond sequestration; fingolimod immune; memory cells; fingolimod ... See more keywords
Pathogenic role of tissue-resident memory T cells in autoimmune diseases.
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DOI: 10.1016/j.autrev.2018.03.014
Abstract: The tissue-resident memory T (TRM) cells constitute a newly identified subset of memory T cells which are non-circulating and they persist for long-term in epithelial barrier tissues, including skin, lung, gastrointestinal tract and reproductive tract,… read more here.
Keywords: memory cells; autoimmune diseases; tissue resident; trm cells ... See more keywords