Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202500177
Abstract: Despite the known benefits of exercise, an in‐depth comparison of the effects of regular versus irregular exercise on brain–body interactions and molecular mechanisms remains lacking. This study demonstrates that regular exercise robustly enhances fear memory… read more here.
Keywords: memory extinction; versus irregular; fear memory; irregular exercise ... See more keywords
Use of a physiological reflex to standardize vagal nerve stimulation intensity improves data reproducibility in a memory extinction assay
Sign Up to like & getrecommendations! Published in 2021 at "Brain Stimulation"
DOI: 10.1016/j.brs.2021.02.012
Abstract: BACKGROUND Modulating brainstem activity, via electrical vagus nerve stimulation (VNS), influences cognitive functions, including memory. However, controlling for changes in stimulus efficacy during chronic studies, and response variability between subjects, is problematic. OBJECTIVE/HYPOTHESIS We hypothesized… read more here.
Keywords: reflex; vns; stimulation; extinction ... See more keywords
Integration of Parallel Opposing Memories Underlies Memory Extinction
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DOI: 10.1016/j.cell.2018.08.021
Abstract: Summary Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called… read more here.
Keywords: opposing memories; integration parallel; extinction; memory extinction ... See more keywords
Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00168
Abstract: Associative memory is essential for cognition, in which associative memory cells and their plasticity presumably play important roles. The mechanism underlying associative memory extinction vs. maintenance remains unclear, which we have studied in a mouse… read more here.
Keywords: associative memory; memory extinction; plasticity; memory ... See more keywords
A Systematic Review on the Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Memory and Extinction
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2021.655947
Abstract: Anxiety disorders are among the most prevalent mental disorders. Present treatments such as cognitive behavior therapy and pharmacological treatments show only moderate success, which emphasizes the importance for the development of new treatment protocols. Non-invasive… read more here.
Keywords: stimulation; memory extinction; extinction; fear memory ... See more keywords
Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12030463
Abstract: Using an in vivo method for the assessment of polyphosphoinositide (PI) hydrolysis, we examine whether spatial learning and memory extinction cause changes in mGlu5 metabotropic glutamate receptor signaling in the hippocampus and prefrontal cortex. We… read more here.
Keywords: mglu5 receptor; mice; receptor; memory extinction ... See more keywords
Sex differences in acetylcholinesterase modulation during spatial and fear memory extinction in the amygdala; an animal study in the single prolonged stress model of PTSD
Sign Up to like & getrecommendations! Published in 2022 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.359435
Abstract: Background and purpose: Men and women show different reactions to trauma and that is believed to be the reason behind the higher prevalence of post-traumatic stress disorder (PTSD) in women. Cholinergic signaling has long been… read more here.
Keywords: memory extinction; extinction; single prolonged; ptsd ... See more keywords