Trauma induces expansion and activation of a memory‐like Treg population
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0520-122r
Abstract: CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, which suggests that they may react to injury with similar kinetics as memory T cells. Here, we used a mouse burn trauma model to… read more here.
Keywords: activation; mice; trauma; injury ... See more keywords
Phenotypic, proteomic, and functional analyses of cytokine-induced memory-like NK cells show two distinct subsets based on CD16 expression
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20947-1
Abstract: NK cells are innate lymphoid cells that can acquire a memory-like phenotype in vitro when stimulated with IL-12, IL-15, and IL-18. These cytokine-induced memory-like (CIML) NK cells exhibit prolonged lifespan and increased cytotoxicity, making them… read more here.
Keywords: cytokine induced; based cd16; cd16 expression; memory like ... See more keywords
Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116588119
Abstract: Significance Memory-like NK cells (NKG2C+CD57+FcεRIγ–) are established during CMV infection. Here, mass cytometry tracked the in vivo kinetics of CMV-induced memory NK cells generation and identified a unique subset of NKG2C+CD57+FcεRIγlow–dim as potentially prememory-like NK… read more here.
Keywords: memory like; viremic patients; cmv infection; cmv ... See more keywords
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122379119
Abstract: Significance Development of effective cellular therapy strategies against acute myeloid leukemia (AML) remains a major therapeutic challenge. Memory-like natural killer (NK) cells armed with a TCR-like chimeric antigen receptor (CAR) targeting a unique neoepitope presented… read more here.
Keywords: myeloid leukemia; memory like; cells armed; car ... See more keywords
Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2045046
Abstract: ABSTRACT Memory-like responses in innate immune cells confer nonspecific protection against secondary exposures. A number of microbial agents have been found to induce enhanced or diminished recall responses in innate cells, however, studies investigating the… read more here.
Keywords: limosilactobacillus reuteri; memory like; reuteri induces; dendritic cells ... See more keywords
The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00372-22
Abstract: Elimination of human immunodeficiency virus (HIV) reservoirs is a critical endpoint to eradicate HIV. One therapeutic intervention against latent HIV is “shock and kill.” This strategy is based on the transcriptional activation of latent HIV… read more here.
Keywords: cell; memory like; hiv; hodhbt ... See more keywords
Abstract SY30-02: NK cells remember: Engineering NK cell memory-like responses for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1158/1538-7445.am2021-sy30-02
Abstract: Natural killer (NK) cells are innate lymphoid cells that protect against infection and mediate anti-tumor immune responses. NK cell immunotherapy is a promising cellular therapy approach for leukemia, lymphoma, and other cancers. Multiple laboratories have… read more here.
Keywords: memory; immunology; cancer; cell ... See more keywords
Abstract 893: Memory like differentiation enhances in vitro and in vivo NK cell responses against colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-893
Abstract: Metastatic (m) colorectal cancer (CRC) is an incurable, frequently lethal disease present in approximately 25% of newly diagnosed CRC patients, and almost 50% of the patients with CRC will develop metastatic disease. For mCRC, while… read more here.
Keywords: cell; memory like; crc; colorectal cancer ... See more keywords
Abstract 894: Generation of cytokine-induced memory-like PD-L1 t-haNK (NK-92®) cells
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-894
Abstract: Cytokine-induced memory-like NK cells have garnered a lot of attention as cellular therapeutic agents due to their much-increased lifespan in patients and their enhanced memory response upon re-challenge by cytokines or target cells. A key… read more here.
Keywords: like hank; cytokine induced; memory; hank cells ... See more keywords
Memory-like Natural Killer Cell and CD19 Antibody–Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-24-0746
Abstract: The authors report combination therapy of memory-like NK cells, a CD19 leukemia epitope–directed antibody and tyrosine kinase inhibition in models of Ph-like acute lymphoblastic leukemia, to enhance immune response and improve therapeutic outcomes. read more here.
Keywords: like acute; acute lymphoblastic; lymphoblastic leukemia; kinase inhibition ... See more keywords
Development of a novel multiomic sequencing approach to characterize infused donor memory-like NK cells in an immune compatible environment
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2352
Abstract: Background Cytokine-induced memory-like natural killer (mem-NK) cells have an enhanced capacity for proliferation and persistence compared to conventional NK cells and have demonstrated efficacy against myeloid leukemia. However, the absence of a robust methodology to… read more here.
Keywords: mem cells; single cell; infusion; cell ... See more keywords