Trauma induces expansion and activation of a memory‐like Treg population
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0520-122r
Abstract: CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, which suggests that they may react to injury with similar kinetics as memory T cells. Here, we used a mouse burn trauma model to… read more here.
Keywords: activation; mice; trauma; injury ... See more keywords
Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116588119
Abstract: Significance Memory-like NK cells (NKG2C+CD57+FcεRIγ–) are established during CMV infection. Here, mass cytometry tracked the in vivo kinetics of CMV-induced memory NK cells generation and identified a unique subset of NKG2C+CD57+FcεRIγlow–dim as potentially prememory-like NK… read more here.
Keywords: memory like; viremic patients; cmv infection; cmv ... See more keywords
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122379119
Abstract: Significance Development of effective cellular therapy strategies against acute myeloid leukemia (AML) remains a major therapeutic challenge. Memory-like natural killer (NK) cells armed with a TCR-like chimeric antigen receptor (CAR) targeting a unique neoepitope presented… read more here.
Keywords: myeloid leukemia; memory like; cells armed; car ... See more keywords
Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2045046
Abstract: ABSTRACT Memory-like responses in innate immune cells confer nonspecific protection against secondary exposures. A number of microbial agents have been found to induce enhanced or diminished recall responses in innate cells, however, studies investigating the… read more here.
Keywords: limosilactobacillus reuteri; memory like; reuteri induces; dendritic cells ... See more keywords
The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00372-22
Abstract: Elimination of human immunodeficiency virus (HIV) reservoirs is a critical endpoint to eradicate HIV. One therapeutic intervention against latent HIV is “shock and kill.” This strategy is based on the transcriptional activation of latent HIV… read more here.
Keywords: cell; memory like; hiv; hodhbt ... See more keywords
Abstract SY30-02: NK cells remember: Engineering NK cell memory-like responses for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1158/1538-7445.am2021-sy30-02
Abstract: Natural killer (NK) cells are innate lymphoid cells that protect against infection and mediate anti-tumor immune responses. NK cell immunotherapy is a promising cellular therapy approach for leukemia, lymphoma, and other cancers. Multiple laboratories have… read more here.
Keywords: memory; immunology; cancer; cell ... See more keywords
Abstract 893: Memory like differentiation enhances in vitro and in vivo NK cell responses against colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-893
Abstract: Metastatic (m) colorectal cancer (CRC) is an incurable, frequently lethal disease present in approximately 25% of newly diagnosed CRC patients, and almost 50% of the patients with CRC will develop metastatic disease. For mCRC, while… read more here.
Keywords: cell; memory like; crc; colorectal cancer ... See more keywords
NKG2A Represents an Important Immune Checkpoint for Human Cytokine-Induced Memory-like NK Cells in Patients with AML
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.167.167
Abstract: Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell anti-leukemia potential is unclear. Paradigm-shifting reports have shown that NK cells… read more here.
Keywords: like cells; cytokine induced; induced memory; memory like ... See more keywords
Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02796
Abstract: Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness. Besides their innate cytotoxic and… read more here.
Keywords: cells remembering; remembering previous; like cells; cell ... See more keywords
Memory-like innate lymphoid cells in the pathogenesis of asthma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1005517
Abstract: Innate lymphoid cells (ILCs) are recently discovered innate immune cells that reside and self-renew in mucosal tissues and serve as the first line of defense against various external insults. They include natural killer (NK) cells,… read more here.
Keywords: memory like; innate lymphoid; memory; innate ... See more keywords
Cytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.884648
Abstract: Natural killer (NK) cells are lymphocytes with a key role in the defense against viral infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs), under certain circumstances they exhibit adaptive… read more here.
Keywords: memory like; cytokine induced; induced memory; memory ... See more keywords