Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.11.008
Abstract: CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to… read more here.
Keywords: cd8; cd8 cells; effector cd8; memory phenotype ... See more keywords
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17136-1
Abstract: CD4+ T lymphocytes consist of naïve, antigen-specific memory, and memory-phenotype (MP) cell compartments at homeostasis. We recently showed that MP cells exert innate-like effector function during host defense, but whether MP CD4+ T cells are… read more here.
Keywords: cd4; bethigh memory; memory phenotype; differentiation ... See more keywords
Eomes identifies thymic precursors of self-specific memory-phenotype CD8+ T cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature immunology"
DOI: 10.1038/s41590-020-0653-1
Abstract: Unprimed mice harbor a substantial population of ‘memory-phenotype’ CD8+ T cells (CD8-MP cells) that exhibit hallmarks of activation and innate-like functional properties. Due to the lack of faithful markers to distinguish CD8-MP cells from bona… read more here.
Keywords: cd8 cells; phenotype cd8; memory phenotype; cd8 ... See more keywords