The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection.
Sign Up to like & getrecommendations! Published in 2022 at "Nature immunology"
DOI: 10.1038/s41590-022-01150-0
Abstract: Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as memory formation. However, the molecular mechanisms by which NK cells persist to form memory cells are not well understood. Using… read more here.
Keywords: viral infection; precursor cells; memory precursor; infection ... See more keywords
Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c8bm01556b
Abstract: Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the… read more here.
Keywords: tumor; redox responsive; reactive cells; cell ... See more keywords