MEN1 Deficiency‐Driven Activation of the β‐Catenin‐MGMT Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers Temozolomide Resistance
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DOI: 10.1002/advs.202308417
Abstract: O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ). However, the biological importance of MGMT and the… read more here.
Keywords: men1; catenin; mgmt; expression ... See more keywords
Preoperative Imaging Overestimates the Tumor Size in Pancreatic Neuroendocrine Neoplasms Associated with Multiple Endocrine Neoplasia Type 1
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DOI: 10.1007/s00268-017-4317-8
Abstract: BackgroundRadiological tumor size of non-functioning pancreatic neuroendocrine neoplasms (Nf-pNENs) associated with multiple endocrine neoplasia type 1 (MEN1) is a crucial parameter to indicate surgery. The aim of this study was to compare radiological size (RS)… read more here.
Keywords: tumor size; pancreatic neuroendocrine; associated multiple; neuroendocrine neoplasms ... See more keywords
From Initial Description by Wermer to Present-Day MEN1: What have We Learned?
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DOI: 10.1007/s00268-017-4435-3
Abstract: IntroductionPancreas, parathyroid, and pituitary, are referred to as the “3 Ps” of MEN1. The time has come to move beyond those Ps and begin to discuss (1) prediction, (2) pausing progression, and (3) prevention of… read more here.
Keywords: aggressive disease; wermer present; men1; initial description ... See more keywords
Chemoprevention with Somatuline© Delays the Progression of Pancreatic Neuroendocrine Neoplasms in a Mouse Model of Multiple Endocrine Neoplasia Type 1 (MEN1)
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DOI: 10.1007/s00268-018-4839-8
Abstract: ObjectiveLong-acting synthetic somatostatin analogues (SSA) are an essential part of the treatment of neuroendocrine neoplasms. We evaluated the chemopreventive effects of a long-acting somatostatin analogue on the development of pancreatic neuroendocrine neoplasms (pNENs) in a… read more here.
Keywords: pancreatic neuroendocrine; neuroendocrine neoplasms; group; men1 ... See more keywords
Clinical aspects of multiple endocrine neoplasia type 1
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DOI: 10.1038/s41574-021-00468-3
Abstract: Multiple endocrine neoplasia type 1 (MEN1) is a rare syndrome characterized by the co-occurrence of primary hyperparathyroidism, duodenopancreatic neuroendocrine tumours (NETs) and/or pituitary adenomas. MEN1 can predispose patients to other endocrine and non-endocrine tumours, such… read more here.
Keywords: endocrine; hyperparathyroidism; men1; neuroendocrine tumours ... See more keywords
Syndromic MEN1 Parathyroid Adenomas Consist of Both Subclonal Nodules and Clonally Independent Tumors
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DOI: 10.1093/bjs/znae118.024
Abstract: Primary hyperparathyroidism with parathyroid tumors is a characteristic presentation in Multiple Endocrine Neoplasia Type 1 (MEN1), historically referred to as "primary hyperplasia." The question of whether these tumors signify a multi-glandular clonal disorder or hyperplasia… read more here.
Keywords: men1; loss; syndromic men1; parathyroid adenomas ... See more keywords
Pancreatic imaging in MEN1-Comparison of conventional and SSTR PET/CT imaging in real-life setting.
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DOI: 10.1093/ejendo/lvad035
Abstract: OBJECTIVE Pancreatic neuroendocrine tumors (panNETs) are the leading cause of death in patients with multiple endocrine neoplasia type 1 (MEN1). The role of somatostatin receptor positron emission tomography (SSTR PET/CT) in MEN1 has not been… read more here.
Keywords: pet; men1; conventional imaging; pancreatic imaging ... See more keywords
PO-450 Interplay between coding and non-coding genome in human parathyroid tumours
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DOI: 10.1136/esmoopen-2018-eacr25.961
Abstract: Introduction Parathyroid tumours are the second most common endocrine neoplasia in women, after thyroid cancer. Mutations in the oncosuppressor CDC73 are the key event in most carcinomas whereas alterations in the tumour suppressor MEN1 (located… read more here.
Keywords: 450 interplay; interplay coding; parathyroid; men1 ... See more keywords
MEN1 degradation induced by neddylation and the CUL4B-DCAF7 axis promotes pancreatic neuroendocrine tumor progression.
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DOI: 10.1158/0008-5472.can-22-3599
Abstract: Pancreatic neuroendocrine tumors (PanNETs) are a group of rare sporadic malignant tumors in the pancreas. MEN1 is the most frequently mutated gene in PanNETs. The MEN1-encoded protein is a typical tumor suppressor that forms a… read more here.
Keywords: neddylation; expression; men1; pannet ... See more keywords
Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival
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DOI: 10.1172/jci.insight.147417
Abstract: Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We previously showed that elevated TS exhibits properties of an oncogene and promotes pancreatic… read more here.
Keywords: thymidylate synthase; men1; hts men1; tumor ... See more keywords
Genotype-phenotype correlation in multiple endocrine neoplasia type 1
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DOI: 10.1172/jci.insight.176993
Abstract: BACKGROUND Among patients with multiple endocrine neoplasia type 1 (MEN1), 80% develop duodenopancreatic neuroendocrine tumors (dpNETs), of whom 15%–25% die of metastasis. There is a need to identify biomarkers to predict aggressive disease. MEN1 genotype… read more here.
Keywords: men1; disease; genotype negative; genotype ... See more keywords