Menadione‐induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28356
Abstract: Earlier studies showed that the oxidant menadione (MD) induces apoptosis in certain cells and also has anticancer effects. Most of these studies emphasized the role of the mitochondria in this process. However, the engagement of… read more here.
Keywords: apoptosis u937; induced apoptosis; menadione; u937 cells ... See more keywords
Combining mutagenesis on Glu281 of prenyltransferase NovQ and metabolic engineering strategies for the increased prenylated activity towards menadione
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10470-w
Abstract: Prenyltransferase NovQ is a vital class involved in the biosynthesis of secondary metabolites such as clorobiocin and novobiocin. To investigate the relationship between structure and catalytic properties of NovQ, here, we have analyzed the substrate-binding… read more here.
Keywords: prenyltransferase novq; menadione; combining mutagenesis; glu281 ... See more keywords
Novel antiadipogenic effect of menadione in 3T3-L1 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109491
Abstract: Inhibition of adipocyte differentiation can be used as a strategy for preventing adipose tissue expansion and, consequently, for obesity management. Since reactive oxygen species (ROS) have emerged as key modulators of adipogenesis, the effect of… read more here.
Keywords: fatty acid; pi3k akt; menadione; effect menadione ... See more keywords
Protective effect of 1950 MHz electromagnetic field in human neuroblastoma cells challenged with menadione
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31636-7
Abstract: This study aims to assess whether a 1950 MHz radiofrequency (RF) electromagnetic field could protect human neuroblastoma SH-SY5Y cells against a subsequent treatment with menadione, a chemical agent inducing DNA damage via reactive oxygen species… read more here.
Keywords: electromagnetic field; neuroblastoma; 1950 mhz; menadione ... See more keywords
139 Effect of lycopene supplementation in maturation medium on production of reactive oxygen species and post-vitrification quality of bovine blastocysts
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv33n2ab139
Abstract: Excessive production and accumulation of reactive oxygen species (ROS) may cause embryo damage associated with oxidative stress. Lycopene, a natural antioxidant, can scavenge singlet oxygen and is one of the most effective antioxidants among carotenoids.… read more here.
Keywords: quality; lycopene; maturation; medium ... See more keywords
Docosahexaenoic Acid Potentiates the Anticancer Effect of the Menadione/Ascorbate Redox Couple by Increasing Mitochondrial Superoxide and Accelerating ATP Depletion
Sign Up to like & getrecommendations! Published in 2023 at "AntiCancer Research"
DOI: 10.21873/anticanres.16268
Abstract: Background/Aim: Mitochondria-targeted anticancer drugs (“mitocans”) of natural origin are attractive candidates as adjuvants in cancer therapy. The redox couple menadione/ascorbate (M/A), which belongs to the “mitocans” family, induces selective oxidative stress in cancerous mitochondria and… read more here.
Keywords: superoxide; mitochondrial superoxide; menadione; anticancer effect ... See more keywords
Anharmonicity and Spectra–Structure Correlations in MIR and NIR Spectra of Crystalline Menadione (Vitamin K3)
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26226779
Abstract: Mid-infrared (MIR) and near-infrared (NIR) spectra of crystalline menadione (vitamin K3) were measured and analyzed with aid of quantum chemical calculations. The calculations were carried out using the harmonic approach for the periodic model of… read more here.
Keywords: spectra crystalline; menadione; crystalline menadione; structure ... See more keywords
Menadione: a platform and a target to valuable compounds synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.43
Abstract: Naphthoquinones are important natural or synthetic compounds belonging to the general class of quinones. Many compounds in this class have become drugs that are on the pharmaceutical market for the treatment of various diseases. A… read more here.
Keywords: valuable compounds; target valuable; platform target; menadione ... See more keywords