Mendelian randomisation with coarsened exposures
Sign Up to like & getrecommendations! Published in 2021 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22376
Abstract: A key assumption in Mendelian randomisation is that the relationship between the genetic instruments and the outcome is fully mediated by the exposure, known as the exclusion restriction assumption. However, in epidemiological studies, the exposure… read more here.
Keywords: assumption; randomisation; exposure; mendelian randomisation ... See more keywords
Polyunsaturated fatty acids and risk of melanoma: A Mendelian randomisation analysis
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31334
Abstract: Melanoma is the deadliest form of skin cancer, mainly affecting populations of European ancestry. Some observational studies suggest that particular diets reduce melanoma risk, putatively through an increase in polyunsaturated fatty acid (PUFA) consumption. However,… read more here.
Keywords: melanoma; pufa; risk; polyunsaturated fatty ... See more keywords
Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-05019-0
Abstract: Aims/hypothesis Epidemiological data on the associations of circulating fatty acid levels with type 2 diabetes are inconsistent. We conducted a two-sample Mendelian randomisation study to explore the causal associations of plasma levels of ten fatty… read more here.
Keywords: glycaemic traits; fatty acids; mendelian randomisation; type diabetes ... See more keywords
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.09.031
Abstract: Background and aims Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The… read more here.
Keywords: vascular remodelling; subclinical vascular; associated snp; mendelian randomisation ... See more keywords
Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
Sign Up to like & getrecommendations! Published in 2022 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2022.103865
Abstract: Summary Background Calcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects… read more here.
Keywords: review; phenome wide; calcium; mendelian randomisation ... See more keywords
Cigarette smoking and personality: interrogating causality using Mendelian randomisation
Sign Up to like & getrecommendations! Published in 2018 at "Psychological Medicine"
DOI: 10.1017/s0033291718003069
Abstract: Abstract Background Despite the well-documented association between smoking and personality traits such as neuroticism and extraversion, little is known about the potential causal nature of these findings. If it were possible to unpick the association… read more here.
Keywords: association; mendelian randomisation; personality; smoking personality ... See more keywords
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Cancer"
DOI: 10.1038/s41416-020-01083-1
Abstract: Background The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors. Methods We… read more here.
Keywords: phenome wide; glioma; study; mendelian randomisation ... See more keywords
Assessing the role of cortisol in cancer: a wide-ranged Mendelian randomisation study.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01505-8
Abstract: BACKGROUND Cortisol's immunosuppressive, obesogenic, and hyperglycaemic effects suggest that it may play a role in cancer development. However, whether cortisol increases cancer risk is not known. We investigated the potential causal association between plasma cortisol… read more here.
Keywords: cortisol; risk; plasma cortisol; mendelian randomisation ... See more keywords
The role of vitamin C in pneumonia and COVID-19 infection in adults with European ancestry: a Mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Clinical Nutrition"
DOI: 10.1038/s41430-021-00993-4
Abstract: High dose vitamin C infusion has been proposed to treat critically ill patients, including patients with pneumonia and severe COVID-19. However, trials have shown mixed findings. Here we assessed the unconfounded associations of vitamin C… read more here.
Keywords: study; covid; mendelian randomisation; vitamin ... See more keywords
Lifetime serum concentration of 25-hydroxyvitamin D 25(OH) is associated with hand grip strengths: insight from a Mendelian randomisation
Sign Up to like & getrecommendations! Published in 2022 at "Age and Ageing"
DOI: 10.1093/ageing/afac079
Abstract: Abstract Clinical trials have suggested that increased 25-hydroxyvitamin D (25(OH)D) has positive effect on hand grip strength. This Mendelian randomisation (MR) was implemented using summary-level data from the largest genome-wide association studies on vitamin D… read more here.
Keywords: grip strengths; hand; hand grip; mendelian randomisation ... See more keywords
Frailty and cardiometabolic diseases: a bidirectional Mendelian randomisation study.
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DOI: 10.1093/ageing/afac256
Abstract: BACKGROUND Frailty is strongly associated with cardiometabolic diseases in observational studies. However, whether the observed association reflects causality requires clarification. We performed a bidirectional Mendelian randomisation (MR) study to assess the causal relationship of frailty,… read more here.
Keywords: randomisation study; mendelian randomisation; frailty; bidirectional mendelian ... See more keywords