Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51702
Abstract: We conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment… read more here.
Keywords: women reproductive; mendelian randomization; randomization study; ischemic stroke ... See more keywords
Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study
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DOI: 10.1002/ana.25693
Abstract: Observational epidemiological studies have reported a relationship between coffee intake and risk of stroke. However, evidence for this association is inconsistent, and it remains uncertain whether the association is causal or due to confounding or… read more here.
Keywords: mendelian randomization; coffee consumption; consumption risk; risk stroke ... See more keywords
Causal effect of psychiatric disorders on epilepsy: A two‐sample Mendelian randomization study
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DOI: 10.1002/brb3.2939
Abstract: This study aims to explore the relationship between psychiatric disorders and the risk of epilepsy using Mendelian randomization (MR) analysis. read more here.
Keywords: psychiatric disorders; mendelian randomization; study; causal effect ... See more keywords
Adiponectin and the risk of gastrointestinal cancers in East Asians: Mendelian randomization analysis
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DOI: 10.1002/cam4.4735
Abstract: Adiponectin is an important adipocytokine and has been associated with the risks of gastrointestinal cancers (GICs). Mendelian randomization (MR) analysis is needed to assess the causal relationships between adiponectin and GICs. read more here.
Keywords: adiponectin; mendelian randomization; gastrointestinal cancers; randomization analysis ... See more keywords
Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study.
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DOI: 10.1002/cam4.6022
Abstract: BACKGROUND Metabolic disorders are a hallmark feature of cancer. However, the evidence for the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still lacking. We performed a two-sample Mendelian randomization (MR)… read more here.
Keywords: mendelian randomization; crc; analysis; colorectal cancer ... See more keywords
Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study
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DOI: 10.1002/ehf2.14016
Abstract: Previous studies investigated the associations between sleep traits and cardiac diseases, but the evidence for the causal inferences was unclear. This study aimed to explore the causal relationship between sleep and cardiac diseases by virtue… read more here.
Keywords: cardiac diseases; mendelian randomization; causal; study ... See more keywords
Use of Mendelian randomization to evaluate the effect of atrial fibrillation on cardiovascular diseases and cardiac death
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DOI: 10.1002/ehf2.14237
Abstract: Several observational studies indicated that atrial fibrillation might aggravate other cardiovascular diseases apart from ischaemic stroke. However, it remains to be determined whether these associations reveal independent causation. Using Mendelian randomization (MR), we systematically investigated… read more here.
Keywords: mendelian randomization; cardiovascular diseases; cardiac death; diseases cardiac ... See more keywords
Constrained instruments and their application to Mendelian randomization with pleiotropy
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22184
Abstract: In Mendelian randomization (MR), inference about causal relationship between a phenotype of interest and a response or disease outcome can be obtained by constructing instrumental variables from genetic variants. However, MR inference requires three assumptions,… read more here.
Keywords: pleiotropy; mendelian randomization; genetic variants; instrumental variables ... See more keywords
Weak and pleiotropy robust sex‐stratified Mendelian randomization in the one sample and two sample settings
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DOI: 10.1002/gepi.22512
Abstract: Mendelian randomization (MR) leverages genetic data as an instrumental variable to provide estimates for the causal effect of an exposure X on a health outcome Y that is robust to confounding. Unfortunately, horizontal pleiotropy—the direct… read more here.
Keywords: randomization; sample; mendelian randomization; weak pleiotropy ... See more keywords
MR‐BOIL: Causal inference in one‐sample Mendelian randomization for binary outcome with integrated likelihood method
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DOI: 10.1002/gepi.22520
Abstract: Mendelian randomization is a statistical method for inferring the causal relationship between exposures and outcomes using an economics‐derived instrumental variable approach. The research results are relatively complete when both exposures and outcomes are continuous variables.… read more here.
Keywords: boil; mendelian randomization; causal; method ... See more keywords
Diabetes and cancer risk: A Mendelian randomization study
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DOI: 10.1002/ijc.32310
Abstract: Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it… read more here.
Keywords: risk; mendelian randomization; study; cancer risk ... See more keywords