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   Articles with "mendelian randomization" as a keyword



Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study

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recommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51702

Abstract: We conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment… read more here.

Keywords: women reproductive; mendelian randomization; randomization study; ischemic stroke ... See more keywords
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Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

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recommendations! Published in 2020 at "Annals of Neurology"

DOI: 10.1002/ana.25693

Abstract: Observational epidemiological studies have reported a relationship between coffee intake and risk of stroke. However, evidence for this association is inconsistent, and it remains uncertain whether the association is causal or due to confounding or… read more here.

Keywords: mendelian randomization; coffee consumption; consumption risk; risk stroke ... See more keywords

Obesity and Multiple Sclerosis Severity: A Mendelian Randomization Study

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recommendations! Published in 2024 at "Annals of Neurology"

DOI: 10.1002/ana.27112

Abstract: Obesity is implicated in the development of multiple sclerosis (MS), but its effect on disability is less well‐established. This study examined the effects of various obesity measures on MS severity in 12,584 MS cases, using… read more here.

Keywords: obesity; study; multiple sclerosis; mendelian randomization ... See more keywords

Exploring the link between antihypertensive drugs targets and pancreatitis risk through Mendelian randomization.

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recommendations! Published in 2025 at "British journal of clinical pharmacology"

DOI: 10.1002/bcp.70374

Abstract: BACKGROUND Observational studies indicate an association between antihypertensive drugs and the risk of acute pancreatitis (AP) and chronic pancreatitis (CP). This study aims to utilize Mendelian randomization (MR) analysis to assess the causal impact of… read more here.

Keywords: genetic proxies; antihypertensive drugs; risk; mendelian randomization ... See more keywords

Association Between Socioeconomic Status and Major Congenital Anomalies: A Two‐Sample Mendelian Randomization Study

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recommendations! Published in 2025 at "Birth Defects Research"

DOI: 10.1002/bdr2.2524

Abstract: Traditional observational studies suggest that socioeconomic status (SES) may influence the risk of congenital anomalies; however, an association remains unclear due to residual confounding. This study used Mendelian randomization (MR) to explore the potential causal… read more here.

Keywords: association; congenital anomalies; mendelian randomization; socioeconomic status ... See more keywords

Causal effect of psychiatric disorders on epilepsy: A two‐sample Mendelian randomization study

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recommendations! Published in 2023 at "Brain and Behavior"

DOI: 10.1002/brb3.2939

Abstract: This study aims to explore the relationship between psychiatric disorders and the risk of epilepsy using Mendelian randomization (MR) analysis. read more here.

Keywords: psychiatric disorders; mendelian randomization; study; causal effect ... See more keywords

Causal link between oxidative stress and epilepsy: A two‐sample Mendelian randomization study

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recommendations! Published in 2024 at "Brain and Behavior"

DOI: 10.1002/brb3.3549

Abstract: Although a growing body of research has indicated a strong link between oxidative stress and epilepsy, the exact nature of their interaction remains elusive. To elucidate this intricate relationship, we conducted a bidirectional Mendelian randomization… read more here.

Keywords: stress epilepsy; mendelian randomization; oxidative stress; link oxidative ... See more keywords

Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization

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recommendations! Published in 2024 at "Brain and Behavior"

DOI: 10.1002/brb3.70051

Abstract: Epilepsy, a complex neurological disorder, is closely linked with structural and functional irregularities in the brain. However, the causal relationship between brain imaging‐derived phenotypes (IDPs) and epilepsy remains unclear. This study aimed to investigate this… read more here.

Keywords: brain; imaging traits; traits epilepsy; mendelian randomization ... See more keywords

Two‐Sample Bidirectional Mendelian Randomization Study With Causal Association Between Metabolic Syndrome and Cerebral Aneurysm

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recommendations! Published in 2025 at "Brain and Behavior"

DOI: 10.1002/brb3.70396

Abstract: We used a two‐sample mendelian randomization (MR) method to comprehensively investigate the causality of metabolic syndrome (MetS) or its components, including MetS, triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), fasting blood glucose… read more here.

Keywords: metabolic syndrome; cerebral aneurysm; mendelian randomization; two sample ... See more keywords

Assessing Causality Between Plasma Brain‐Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study

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recommendations! Published in 2025 at "Brain and Behavior"

DOI: 10.1002/brb3.70425

Abstract: This study employed a two‐sample Mendelian randomization (MR) approach to investigate the bidirectional relationship between brain‐derived neurotrophic factor (BDNF) and major depressive disorder (MDD), addressing gaps left by prior observational studies. read more here.

Keywords: neurotrophic factor; brain; study; mendelian randomization ... See more keywords

Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation

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recommendations! Published in 2025 at "Brain and Behavior"

DOI: 10.1002/brb3.70435

Abstract: Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179… read more here.

Keywords: sample mendelian; aneurysm; mendelian randomization; intracranial aneurysm ... See more keywords