Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-017-9385-8
Abstract: Menin, the protein encoded by the MEN1 gene, is abundantly expressed in the epithelial cells of mammary glands. Here, we found MEN1/menin expression slowly decreased with advancing lactation but increased by the end of lactation.… read more here.
Keywords: epithelial cell; mammary epithelial; mammary glands; menin ... See more keywords
Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00789
Abstract: Targeting the menin-MLL protein-protein interaction is being pursued as a new therapeutic strategy for the treatment of acute leukemia carrying MLL-rearrangements (MLLr leukemia). Herein, we report M-1121, a covalent and orally active inhibitor of the… read more here.
Keywords: orally active; menin; covalent; interaction ... See more keywords
Discovery of Novel, Potent, and Selective Small-Molecule Menin-Mixed Lineage Leukemia Interaction Inhibitors through Attempting Introduction of Hydrophilic Groups.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01313
Abstract: Introduction of the N,N-dimethylaminoethoxy group to pyrido[3,2-d]pyrimidine led to the discovery of menin-mixed lineage leukemia (MLL) interaction inhibitor C20. C20 showed strong binding affinity to menin protein and achieved sub-micromolar potency in cell growth inhibition.… read more here.
Keywords: interaction; lineage leukemia; menin mixed; menin ... See more keywords
Therapeutic implications of menin inhibition in acute leukemias
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01309-y
Abstract: Menin inhibitors are novel targeted agents currently in clinical development for the treatment of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in endocrine glands. Germline mutations in the gene encoding… read more here.
Keywords: acute leukemia; menin; menin inhibition; acute leukemias ... See more keywords
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Sign Up to like & getrecommendations! Published in 2022 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00603-3
Abstract: Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressing mutant… read more here.
Keywords: menin inhibitor; menin; based combinations; inhibitor ... See more keywords
The potential of β‐cell growth promotion, continued
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13396
Abstract: A recent commentary in the Journal of Diabetes described new approaches to type 1 diabetes (T1D), pointing out that reduction in β-cell proliferative capacity may be an underrecognized contributor to the development of T1D. A… read more here.
Keywords: cell; cell growth; menin; cell mass ... See more keywords
The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15301
Abstract: MEN1, which encodes menin protein, is the most frequently mutated gene in pancreatic neuroendocrine neoplasms (pNEN). Pleiotrophin (PTN) was reported being a downstream factor of menin and to promote metastasis in different tumor entities. In… read more here.
Keywords: ptn; menin; pancreatic neuroendocrine; metastasis ... See more keywords
Loss of MLL induces epigenetic dysregulation of Rasgrf1 to attenuate Kras-driven lung tumorigenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-1475
Abstract: Menin is necessary for the formation of the menin/MLL complex and is recruited directly to chromatin. Menin is an important tumor suppressor in several cancer types, including lung cancer. Here, we investigated the role of… read more here.
Keywords: rasgrf1; menin; lung tumorigenesis; cancer ... See more keywords
Abstract 3457: Characterization of acquired resistance mutations to menin inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3457
Abstract: The menin-MLL1 interaction is critical for development of acute leukemias driven by MLL1 rearrangements (MLLr) or mutations in the Nucleophosmin 1 gene (NPM1c). Inhibition of the menin-MLL1 interaction by SNDX-5613 (revumenib) has demonstrated robust clinical… read more here.
Keywords: acquired resistance; characterization acquired; menin inhibitors; menin ... See more keywords
Abstract 473: Covalent menin inhibitor, BMF-219, impacts key gene signatures and molecular pathways in chronic lymphocytic leukemia patient-derived models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-473
Abstract: Chronic lymphocytic Leukemia (CLL) is the most common type of adult leukemia characterized by clonal proliferation of malignant B-lymphocytes. Although standard-of-care agents are well tolerated in CLL, patients with certain genetic subsets of the disease… read more here.
Keywords: leukemia; inhibitor; menin; bmf 219 ... See more keywords
Abstract LB314: Epigenetic regulator Menin-MLL1 maintains cancer stem cells and promotes neuroblastoma growth
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb314
Abstract: Epigenetic regulators MLL1 and Menin plays important role in cancer progression, metastasis, and relapse. Apart from the oncogenic translocations in leukemias, MLL1 forms a COMPASS complex with Menin and other binding partners to act as… read more here.
Keywords: growth; menin; tumor; menin mll1 ... See more keywords