Abstract 3457: Characterization of acquired resistance mutations to menin inhibitors
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DOI: 10.1158/1538-7445.am2023-3457
Abstract: The menin-MLL1 interaction is critical for development of acute leukemias driven by MLL1 rearrangements (MLLr) or mutations in the Nucleophosmin 1 gene (NPM1c). Inhibition of the menin-MLL1 interaction by SNDX-5613 (revumenib) has demonstrated robust clinical… read more here.
Keywords: acquired resistance; characterization acquired; menin inhibitors; menin ... See more keywords