Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
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DOI: 10.1002/ijc.35332
Abstract: Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation… read more here.
Keywords: lessons learned; menin kmt2a; leukemia; kmt2a interaction ... See more keywords
Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Haematologica"
DOI: 10.3324/haematol.2024.285616
Abstract: Acute myeloid leukemia (AML) remains challenging to treat, which in part relates to genetic heterogeneity of the disease, to the protective tumor microenvironment driving resistance to therapy, and also to immune evasion characteristics of leukemic… read more here.
Keywords: menin kmt2a; acute myeloid; proliferation; jnj 75276617 ... See more keywords