Abstract LB314: Epigenetic regulator Menin-MLL1 maintains cancer stem cells and promotes neuroblastoma growth
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb314
Abstract: Epigenetic regulators MLL1 and Menin plays important role in cancer progression, metastasis, and relapse. Apart from the oncogenic translocations in leukemias, MLL1 forms a COMPASS complex with Menin and other binding partners to act as… read more here.
Keywords: growth; menin; tumor; menin mll1 ... See more keywords
The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
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DOI: 10.1182/blood.2021012806
Abstract: Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of… read more here.
Keywords: fusion; nup98 fusion; leukemia; menin mll1 ... See more keywords
Menin–MLL1 Interaction Small Molecule Inhibitors: A Potential Therapeutic Strategy for Leukemia and Cancers
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DOI: 10.3390/molecules28073026
Abstract: Encoded by the MEN1 gene, menin protein is a fusion protein that is essential for the oncogenic transformation of mixed-lineage leukemia (MLL) and leads to acute leukemia (AL). Therefore, accumulating evidence has demonstrated that inhibition… read more here.
Keywords: small molecule; mll1 interaction; leukemia; menin mll1 ... See more keywords