Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100679
Abstract: The enzymes of the 2‐C‐methylerythritol‐d‐erythritol 4‐phosphate (MEP) pathway (MEP pathway or non‐mevalonate pathway) are responsible for the synthesis of universal precursors of the large and structurally diverse family of isoprenoids. This pathway is absent in… read more here.
Keywords: enzyme mep; novel fragment; mep pathway; pathway ... See more keywords
Metabolic Engineering of the MEP Pathway in Bacillus subtilis for Increased Biosynthesis of Menaquinone-7.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00077
Abstract: Vitamin K is essential for blood coagulation and plays important roles in bone and cardiovascular health. Menaquinone-7 (MK-7) is one form of vitamin K that is especially useful due to its long half-life in the… read more here.
Keywords: mep pathway; metabolic engineering; engineering mep; menaquinone ... See more keywords
Transcriptome profiling of spike provides expression features of genes related to terpene biosynthesis in lavender
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63950-4
Abstract: Lavender ( Lavandula angustifolia ) is an important economic plant because of the value of its essential oil (EO). The Yili Valley in Xinjiang has become the largest lavender planting base in China. However, there… read more here.
Keywords: terpene biosynthesis; mep pathway; biosynthesis; lavender ... See more keywords
Systematic Analysis of Metabolic Bottlenecks in the Methylerythritol 4-Phosphate (MEP) Pathway of Zymomonas mobilis
Sign Up to like & getrecommendations! Published in 2023 at "mSystems"
DOI: 10.1128/msystems.00092-23
Abstract: Engineered microorganisms have the potential to convert renewable substrates into biofuels and valuable bioproducts, which offers an environmentally sustainable alternative to fossil-fuel-derived products. Isoprenoids are a diverse class of biologically derived compounds that have commercial… read more here.
Keywords: zymomonas mobilis; metabolic bottlenecks; mobilis; mep pathway ... See more keywords
Transcriptomic profiling reveals MEP pathway contributing to ginsenoside biosynthesis in Panax ginseng
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5718-x
Abstract: BackgroundPanax ginseng C. A. Mey is one of famous medicinal herb plant species. Its major bioactive compounds are various ginsenosides in roots and rhizomes. It is commonly accepted that ginsenosides are synthesized from terpene precursors,… read more here.
Keywords: ginseng; mep pathway; mva pathway; ginsenoside biosynthesis ... See more keywords
Engineering Pseudomonas putida for isoprenoid production by manipulating endogenous and shunt pathways supplying precursors
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1204-z
Abstract: BackgroundThe soil bacterium Pseudomonas putida is a promising platform for the production of industrially valuable natural compounds. In the case of isoprenoids, the availability of biosynthetic precursors is a major limiting factor. In P. putida… read more here.
Keywords: mep pathway; engineering pseudomonas; production; pseudomonas putida ... See more keywords
Cloning, characterization, and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene from Dioscorea zingiberensis
Sign Up to like & getrecommendations! Published in 2019 at "Biologia plantarum"
DOI: 10.32615/bp.2019.030
Abstract: Diosgenin, mainly extracted from some Dioscorea species, is the most important starting material for the production of steroidal drugs. It is believed that diosgenin in Dioscorea is synthesized from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate… read more here.
Keywords: expression; deoxy xylulose; mep pathway; zingiberensis ... See more keywords
Engineering Production of a Novel Diterpene Synthase Precursor in Nicotiana benthamiana
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.757186
Abstract: Diterpene biosynthesis commonly originates with the methylerythritol phosphate (MEP) pathway in chloroplasts, leading to the C20 substrate, geranylgeranyl pyrophosphate (GGPP). The previous work demonstrated that over-expression of genes responsible for the first and last steps… read more here.
Keywords: combination; mep pathway; pyrophosphate; synthase ... See more keywords
YdfD, a Lysis Protein of the Qin Prophage, Is a Specific Inhibitor of the IspG-Catalyzed Step in the MEP Pathway of Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031560
Abstract: Bacterial cryptic prophage (defective prophage) genes are known to drastically influence host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages encode lytic proteins to destroy the cell envelope. As natural… read more here.
Keywords: cell; prophage; lysis; mep pathway ... See more keywords
Monoterpenoids Evolution and MEP Pathway Gene Expression Profiles in Seven Table Grape Varieties
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11162143
Abstract: This research investigated the evolution of both monoterpenoids and expression profiles of related biosynthesis genes in the MEP pathway in seven different table grape varieties from veraison to maturity stage in two seasons, and the… read more here.
Keywords: table grape; expression profiles; mep pathway; gene ... See more keywords
Expression and promoter analysis of MEP pathway enzyme-encoding genes in Pinus massoniana Lamb
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13266
Abstract: The methylerythritol phosphate (MEP) pathway provides the universal basic blocks for the biosynthesis of terpenoids and plays a critical role in the growth and development of higher plants. Pinus massoniana is the most valuable oleoresin… read more here.
Keywords: mep pathway; expression; pinus massoniana; enzyme encoding ... See more keywords