Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01000
Abstract: Protein arginine methyltransferase 5 (PRMT5) is a master epigenetic regulator and an extensively validated therapeutic target in multiple cancers. Notably, PRMT5 is the only PRMT that requires an obligate cofactor, methylosome protein 50 (MEP50), to… read more here.
Keywords: prmt5 mep50; protein protein; mep50 protein; prmt5 ... See more keywords