Excretion of mephedrone and its phase I metabolites in urine after a controlled intranasal administration to healthy human volunteers
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3214
Abstract: Abstract Mephedrone is a stimulant drug structurally related to cathinone. At present, there are no data available on the excretion profile of mephedrone and its metabolites in urine after controlled intranasal administration to human volunteers.… read more here.
Keywords: administration; mephedrone; metabolites urine; intranasal administration ... See more keywords
Effects of cocaine on the discriminative stimulus and reinforcing effects of mephedrone in male rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5110-6
Abstract: RationaleAbuse of cathinones has been a worldwide health concern for some time. Their chemical structures and wide variation in pharmacodynamic effects have led to clinical and preclinical effects that can be both similar to and… read more here.
Keywords: reinforcing effects; discriminative stimulus; mephedrone; cocaine ... See more keywords
Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05241-z
Abstract: RationaleThe underlying pharmacological mechanisms of mephedrone, especially as related to interactions with different neurotransmitter systems, are a critical area of study as mephedrone continues to be abused.ObjectiveDirect-acting 5-HT2A/2C receptor agonists and antagonists and D1–3 receptor… read more here.
Keywords: trained discriminate; training dose; mephedrone; rats trained ... See more keywords
Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study
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DOI: 10.1007/s12035-021-02404-y
Abstract: Mephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone… read more here.
Keywords: rewarding effects; involvement rewarding; study; mephedrone ... See more keywords
A comparison of mitochondrial toxicity of mephedrone on three separate parts of brain including hippocampus, cortex and cerebellum.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.02.014
Abstract: Mephedrone (4-methylmethcathinone) is a new and popular drug of abuse and also widely available on the internet and still legal in some parts of the world. The central nervous system is the target of mephedrone… read more here.
Keywords: hippocampus cortex; brain; cortex cerebellum; mephedrone ... See more keywords
Toxicity of new synthetic amphetamine drug mephedrone On Rat Heart mitochondria: a warning for its abuse
Sign Up to like & getrecommendations! Published in 2018 at "Xenobiotica"
DOI: 10.1080/00498254.2017.1401753
Abstract: Abstract 1. Mephedrone, a new and popular amphetamine drug, is widely abused and is still legal in some parts around the world. Little data on mechanisms involved in mephedrone induced cardiotoxicity are available. 2. Therefore, we decided… read more here.
Keywords: heart; mephedrone; amphetamine drug; heart mitochondria ... See more keywords
Mephedrone as a new synthetic amphetamine induces abortion, morphological alterations and mitochondrial dysfunction in mouse embryos
Sign Up to like & getrecommendations! Published in 2020 at "Toxin Reviews"
DOI: 10.1080/15569543.2020.1803358
Abstract: Abstract We have studied the embryo-fetal toxicity of mephedrone in mice during organogenesis period on gestation day (GD) 6–15 in mice during organogenesis period intraperitoneally. Our observation showed that mephedrone induces abortion, reduction in the… read more here.
Keywords: mouse; embryo fetal; induces abortion; mephedrone ... See more keywords
Mephedrone induced apoptosis and impaired neurogenesis in embryonic neural stem/progenitor cells.
Sign Up to like & getrecommendations! Published in 2023 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0350
Abstract: INTRODUCTION Mephedrone, a synthetic derivative of cathinone, is a commonly used psychoactive substance. Exposure to mephedrone during pregnancy induced antiproliferative and proapoptotic effects in hippocampous of mice delivered pups. The aim of present study is… read more here.
Keywords: apoptosis; mephedrone; proliferation; mephedrone induced ... See more keywords