CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor
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DOI: 10.1007/s00125-019-4893-2
Abstract: To the Editor: The CD40-CD40 ligand (CD40L, also known as CD154) pathway has been identified as a potential target for pharmaceutical intervention in type 1 diabetes [1, 2]. The CD40-targeted peptide approach published by Wagner… read more here.
Keywords: affinity; mer peptide; cd40l; cd40 ... See more keywords
Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B.
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DOI: 10.1021/jacs.8b06755
Abstract: Polytheonamide B (1) is a unique peptide natural product because of its extremely complex structure, a channel-forming ability in vitro, and the extremely potent cytotoxicity. The 48-mer sequence of 1 comprises alternating d,l-amino acids and… read more here.
Keywords: mer peptide; solid phase; channel; total synthesis ... See more keywords