Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Science of Food and Agriculture"
DOI: 10.1002/jsfa.14045
Abstract: Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the… read more here.
Keywords: catechins resveratrol; mercaptopurine; xanthine oxidase; catalyzed xanthine ... See more keywords
Influence of xanthine oxidase and inosine monophosphate dehydrogenase polymorphisms on 6-mercaptopurine treatment response in pediatric acute lymphoblastic leukemia
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DOI: 10.1038/s41598-025-24355-3
Abstract: Over the past decades, survival outcomes for childhood acute lymphoblastic leukaemia (ALL) have significantly improved. However, adverse drug reactions (ADRs), particularly those related to 6-mercaptopurine (6-MP), remain a major concern. Myelosuppression associated with 6-MP administration… read more here.
Keywords: treatment; acute lymphoblastic; response; mercaptopurine ... See more keywords
A novel polymeric micelle-decorated Fe3O4/Au core–shell nanoparticle for pH and reduction-responsive intracellular co-delivery of doxorubicin and 6-mercaptopurine
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj03310b
Abstract: Cancer is one of the most common health problems which leads to death in the world, and an impressive approach to clinical cancer treatment is combination chemotherapy. To address this concern, multi-anticancer agents have been… read more here.
Keywords: mercaptopurine; delivery; novel polymeric; drug ... See more keywords
Design and fabrication of poly(HPMA)–6-mercaptopurine conjugates and their in vitro anticancer effect
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DOI: 10.1039/c8nj04039g
Abstract: In this work, a new kind of polymer system based on poly(N-(2-hydroxypropyl)methacrylamide) (poly(HPMA)) for transporting the anticancer drug 6-mercaptopurine (6MP) was successfully prepared. The vinyl groups were grafted onto the polymer chains via the reaction… read more here.
Keywords: mercaptopurine; poly hpma; hpma; effect ... See more keywords
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002434
Abstract: 6-mercaptopurine is a mainstay of acute lymphoblastic leukemia treatment. It has a narrow therapeutic window, dictated by its metabolite, thioguanine and 6-methylmercaptopurine. Skin manifestations usually consist of mild facial rash or hypersensitivity exanthems. We report… read more here.
Keywords: metabolism; rash; lymphoblastic leukemia; mercaptopurine ... See more keywords
Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 Children With Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002609
Abstract: Mercaptopurine (6MP) and methotrexate are the cornerstones of maintenance therapy in pediatric patients with acute lymphoblastic leukemia. However, although bone marrow suppression and liver dysfunction are common side effects of these antimetabolites, 6MP-induced hypoglycemia during… read more here.
Keywords: severe recurrent; lymphoblastic leukemia; hypoglycemia; mercaptopurine ... See more keywords
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial
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DOI: 10.14309/ctg.0000000000000549
Abstract: INTRODUCTION: Chronotherapy is the timing of medication according to biological rhythms of the host to optimize drug efficacy and minimize toxicity. Efficacy and myelosuppression of azathioprine/6-mercaptopurine (AZA/6-MP) are correlated with the metabolite 6-thioguanine, while the… read more here.
Keywords: chronotherapy; inflammatory bowel; crossover trial; bowel disease ... See more keywords
The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1334846
Abstract: Introduction Polymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on mercaptopurine-induced toxicity in… read more here.
Keywords: induced toxicity; genotype; mercaptopurine induced; mercaptopurine ... See more keywords
Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis
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DOI: 10.3390/ijms231911885
Abstract: Thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (6-MP) are used extensively in pediatric and adult patients with inflammatory and neoplastic diseases. They are metabolized to 6-thioguanine nucleotides (6-TGN) or to 6-methyl-mercaptopurine nucleotides (6-MMPN). The balance between… read more here.
Keywords: monitoring data; tgn mmpn; red blood; blood cells ... See more keywords
Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells
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DOI: 10.3390/nano12224029
Abstract: 6-Mercaptopurine (6-MP) is a well-known immunosuppressive medication with proven anti-proliferative activities. 6-MP possesses incomplete and highly variable oral absorption due to its poor water solubility, which might reduce its anti-cancer properties. To overcome these negative… read more here.
Keywords: cancer; formulation; loaded liposomal; mercaptopurine ... See more keywords
Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS
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DOI: 10.3390/scipharm86020018
Abstract: This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leukemia (ALL) patients. Analytes on the DBS card were… read more here.
Keywords: mercaptopurine; blood spots; range; dried blood ... See more keywords