A novel polymeric micelle-decorated Fe3O4/Au core–shell nanoparticle for pH and reduction-responsive intracellular co-delivery of doxorubicin and 6-mercaptopurine
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DOI: 10.1039/c8nj03310b
Abstract: Cancer is one of the most common health problems which leads to death in the world, and an impressive approach to clinical cancer treatment is combination chemotherapy. To address this concern, multi-anticancer agents have been… read more here.
Keywords: mercaptopurine; delivery; novel polymeric; drug ... See more keywords
Design and fabrication of poly(HPMA)–6-mercaptopurine conjugates and their in vitro anticancer effect
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DOI: 10.1039/c8nj04039g
Abstract: In this work, a new kind of polymer system based on poly(N-(2-hydroxypropyl)methacrylamide) (poly(HPMA)) for transporting the anticancer drug 6-mercaptopurine (6MP) was successfully prepared. The vinyl groups were grafted onto the polymer chains via the reaction… read more here.
Keywords: mercaptopurine; poly hpma; hpma; effect ... See more keywords
Acral Skin Rash Caused by Altered Mercaptopurine Metabolism in Maintenance Therapy for B-Cell Acute Lymphoblastic Leukemia
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DOI: 10.1097/mph.0000000000002434
Abstract: 6-mercaptopurine is a mainstay of acute lymphoblastic leukemia treatment. It has a narrow therapeutic window, dictated by its metabolite, thioguanine and 6-methylmercaptopurine. Skin manifestations usually consist of mild facial rash or hypersensitivity exanthems. We report… read more here.
Keywords: metabolism; rash; lymphoblastic leukemia; mercaptopurine ... See more keywords
Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 Children With Acute Lymphoblastic Leukemia
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DOI: 10.1097/mph.0000000000002609
Abstract: Mercaptopurine (6MP) and methotrexate are the cornerstones of maintenance therapy in pediatric patients with acute lymphoblastic leukemia. However, although bone marrow suppression and liver dysfunction are common side effects of these antimetabolites, 6MP-induced hypoglycemia during… read more here.
Keywords: severe recurrent; lymphoblastic leukemia; hypoglycemia; mercaptopurine ... See more keywords
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial
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DOI: 10.14309/ctg.0000000000000549
Abstract: INTRODUCTION: Chronotherapy is the timing of medication according to biological rhythms of the host to optimize drug efficacy and minimize toxicity. Efficacy and myelosuppression of azathioprine/6-mercaptopurine (AZA/6-MP) are correlated with the metabolite 6-thioguanine, while the… read more here.
Keywords: chronotherapy; inflammatory bowel; crossover trial; bowel disease ... See more keywords
Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis
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DOI: 10.3390/ijms231911885
Abstract: Thiopurine drugs azathioprine (AZA) and 6-mercaptopurine (6-MP) are used extensively in pediatric and adult patients with inflammatory and neoplastic diseases. They are metabolized to 6-thioguanine nucleotides (6-TGN) or to 6-methyl-mercaptopurine nucleotides (6-MMPN). The balance between… read more here.
Keywords: monitoring data; tgn mmpn; red blood; blood cells ... See more keywords
Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells
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DOI: 10.3390/nano12224029
Abstract: 6-Mercaptopurine (6-MP) is a well-known immunosuppressive medication with proven anti-proliferative activities. 6-MP possesses incomplete and highly variable oral absorption due to its poor water solubility, which might reduce its anti-cancer properties. To overcome these negative… read more here.
Keywords: cancer; formulation; loaded liposomal; mercaptopurine ... See more keywords
Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS
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DOI: 10.3390/scipharm86020018
Abstract: This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leukemia (ALL) patients. Analytes on the DBS card were… read more here.
Keywords: mercaptopurine; blood spots; range; dried blood ... See more keywords