6-mercaptopurine promotes energetic failure in proliferating T cells
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DOI: 10.18632/oncotarget.17889
Abstract: The anticancer drug 6-mercaptopurine (6-MP) inhibits de novo purine synthesis and acts as an antiproliferative agent by interfering with protein, DNA and RNA synthesis and promoting apoptosis. Metabolic reprogramming is crucial for tumor progression to… read more here.
Keywords: promotes energetic; mercaptopurine promotes; energetic failure; proliferating cells ... See more keywords