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   Articles with "mercaptopyruvate sulfurtransferase" as a keyword



Dihydrolipoic acid improves diabetic endothelial cell function via the H2S-producing enzyme 3-mercaptopyruvate sulfurtransferase.

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recommendations! Published in 2025 at "FEBS letters"

DOI: 10.1002/1873-3468.70239

Abstract: High glucose‐induced endothelial dysfunction is a hallmark of diabetic microvascular complications. Reduced hydrogen sulphide (H2S) levels and dysregulation of the H2S‐producing enzyme 3‐mercaptopyruvate sulfurtransferase (3‐MST) are linked to this dysfunction. Dihydrolipoic acid (DHLA), formed from… read more here.

Keywords: mercaptopyruvate sulfurtransferase; h2s; h2s producing; dihydrolipoic acid ... See more keywords

Multiple role of 3‐mercaptopyruvate sulfurtransferase: antioxidative function, H2S and polysulfide production and possible SOx production

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recommendations! Published in 2018 at "British Journal of Pharmacology"

DOI: 10.1111/bph.14100

Abstract: Rat 3‐mercaptopyruvate sulfurtransferase (MPST) is a 32 808 Da simple protein. Cys247 is a catalytic site, and Cys154 and Cys263 are on the enzyme surface. MPST is found in all tissues, particularly in the kidneys, although… read more here.

Keywords: antioxidative function; production; mercaptopyruvate sulfurtransferase; reducing system ... See more keywords

Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.

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recommendations! Published in 2025 at "Journal of the American Heart Association"

DOI: 10.1161/jaha.125.041440

Abstract: Background Doxorubicin, a broad‐spectrum chemotherapy drug, is often associated with dosage‐dependent cardiotoxicity, which results in its limited clinical application. A therapeutic dose of doxorubicin can activate cardiac ubiquitin‐proteasome system, whereas the role and potential mechanisms… read more here.

Keywords: mercaptopyruvate sulfurtransferase; oxidative stress; hydrogen sulfide; rnf2 ... See more keywords

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12030603

Abstract: 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate with dihydrolipoic… read more here.

Keywords: sulfurtransferase mst; mst; role; mercaptopyruvate sulfurtransferase ... See more keywords

The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells

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recommendations! Published in 2023 at "Biomolecules"

DOI: 10.3390/biom13010144

Abstract: Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the… read more here.

Keywords: biosynthesis; human mercaptopyruvate; mercaptopyruvate sulfurtransferase; moco biosynthesis ... See more keywords