197TiP A randomized, double-blind, phase III study of pembrolizumab plus chemotherapy as first-line therapy in patients with HER2-negative, advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: KEYNOTE-859
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DOI: 10.1016/j.annonc.2020.10.461
Abstract: s Annals of Oncology continue per protocol. Treatment with pembrolizumab/placebo will continue for up to 35 administrations (w2 years) or until disease progression, unacceptable toxicity, intercurrent illness that prevents further administration of treatment, or noncompliance.… read more here.
Keywords: bayer; merck; study; advisory consultancy ... See more keywords
Genome Wide Analysis Reveals Host Genetic Variants that Associate with Reduction in Clostridium difficile Infection Recurrence (rCDI) in Patients Treated with Bezlotoxumab
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DOI: 10.1093/ofid/ofx163.941
Abstract: Abstract Background Bezlotoxumab (BEZ) and actoxumab (ACT) are monoclonal antibodies against C. difficile toxins B and A, respectively. Patients receiving a single infusion of BEZ alone or with ACT in the MODIFY I/II trials showed… read more here.
Keywords: merck inc; rcdi; hold stock; stock ... See more keywords
Modeling Long-Term Cost-Effectiveness of Sitagliptin and SGLT2i Combination Therapy for the Treatment of Type 2 Diabetes
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DOI: 10.2337/db18-1247-p
Abstract: Clinical benefits of dipeptidyl peptidase-4 inhibitors (DPP-4i) and sodium-glucose co-transporter 2 inhibitors (SGLT2i) combination therapy have been demonstrated through clinical trials; however, there is limited understanding of economic benefits of sequential use of these therapies.… read more here.
Keywords: self merck; treatment; merck inc; cost ... See more keywords
Distance from Glycemic Target at the Time of Add-On Initiation in Patients with Type 2 Diabetes (T2D) Failing Metformin Monotherapy in the United States
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DOI: 10.2337/db18-1628-p
Abstract: While it is known that a substantial proportion of U.S. patients with T2D are not at glycemic target, the distance to glycemic target has not been adequately characterized, especially at the time of add-on initiation.… read more here.
Keywords: self merck; employee; merck inc; time ... See more keywords
Conformance to Type 2 Diabetes (T2D) Guidelines in a Large U.S. Health Plan
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DOI: 10.2337/db18-1658-p
Abstract: Almost half of U.S. T2D patients (pts) have suboptimal glycemic control (A1c ≥7%). One factor that may be associated with this is clinical inertia related to physician/patient actions or lack of “conformance” to guidelines. We… read more here.
Keywords: conformance; self merck; conformance type; merck inc ... See more keywords
1119-P: Efficacy and Safety of Sitagliptin (SITA) Compared with Dapagliflozin (DAPA) in People ≥65 Years Old with T2D
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1119-p
Abstract: In the U.S., ~45% of patients with T2D are ≥65 years old, of whom ~50% have mild renal insufficiency (eGFR ≥60 and Treatment groups were well-balanced at baseline (mean A1C [%] = 7.7/7.7, mean eGFR… read more here.
Keywords: merck inc; self merck; employee self;
1149-P: A1C Goal Attainment after Metformin (MET) Uptitration With and Without Sitagliptin (SITA): Impact of Baseline and Target A1C
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DOI: 10.2337/db19-1149-p
Abstract: MET is generally recommended as the initial AHA for T2D, but many patients do not achieve glycemic goal at an initial, sub-maximal dose (500-1000 mg/day) and should intensify therapy. Typically, MET dose is first maximized,… read more here.
Keywords: merck inc; a1c goal; self merck; goal ... See more keywords
1197-P: Two-Year Effects of Ertugliflozin on Renal Function
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DOI: 10.2337/db19-1197-p
Abstract: 2 RCT evaluating ertugliflozin 5 mg (E5, n=652), 15 mg (E15, n=640) vs. non-ertugliflozin (NE, glimepiride or placebo, n=644) in T2D patients were pooled to evaluate effects on eGFR (MDRD) and albuminuria (UACR, geometric mean… read more here.
Keywords: inc; merck inc; self merck; employee self ... See more keywords
2334-PUB: Evolution of the Designs of the Sitagliptin (SITA) Pediatric Clinical Studies
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DOI: 10.2337/db19-2334-pub
Abstract: Approved antihyperglycemic therapies for pediatric patients with T2D are currently limited to metformin (MET) and insulin. SITA is being evaluated in 3 studies in patients 10-17 years of age with T2D: SITA as initial oral… read more here.
Keywords: employee; merck inc; self merck; inc ... See more keywords
1222-P: Implementation of an Electronic Medical Record Tool to Improve Type 2 Diabetes Management in a Large Health System
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DOI: 10.2337/db20-1222-p
Abstract: Guidelines recommend individualized treatment for patients with type 2 diabetes (T2D), avoidance of clinical inertia, and specific therapeutic choices for patients at risk for cardiovascular disease, congestive heart failure, or chronic kidney disease. However, a… read more here.
Keywords: endocrinology; merck inc; tool; inc ... See more keywords
1783-P: Effects of DPP-4 Inhibition on the Enteroinsular Axis in Pancreatic Insufficient Cystic Fibrosis
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DOI: 10.2337/db20-1783-p
Abstract: Impaired incretin secretion may contribute to insulin secretion defects in pancreatic insufficient cystic fibrosis (PI-CF). We hypothesized that dipeptidyl peptidase-4 (DPP-4) inhibitor therapy would increase glucagon-like peptide-1 (GLP-1) and improve insulin secretion in glucose intolerant… read more here.
Keywords: cystic fibrosis; pancreatic insufficient; merck inc; insufficient cystic ... See more keywords