Molecular Mechanisms of the Sense of Touch: An Overview of Mechanical Transduction and Transmission in Merkel Discs of Whisker Hair Follicles and Some Clinical Perspectives.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1756-9_1
Abstract: The Merkel disc is a main type of tactile end organs for sensing gentle touch and is essential for sophisticated sensory tasks including social interaction, environmental exploration, and tactile discrimination. Recent studies have shown that… read more here.
Keywords: whisker; transduction transmission; transmission merkel; merkel discs ... See more keywords
Rémission complète d’un carcinome de Merkel métastatique après pembrolizumab
Sign Up to like & getrecommendations! Published in 2017 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2017.09.245
Abstract: Introduction Le carcinome de Merkel est une tumeur cutanee rare et tres agressive. L’immunotherapie, traitement indique dans le melanome, semble etre une solution de traitement dans cette pathologie. Observation Un homme de 60 ans presentait… read more here.
Keywords: carcinome merkel; cette tumeur; tumeur; une tumeur ... See more keywords
Reviewing the current evidence supporting early B-cells as the cellular origin of Merkel cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2017.05.009
Abstract: Merkel cell carcinoma (MCC) is a highly malignant skin cancer characterized by early metastases and poor survival. Although MCC is a rare malignancy, its incidence is rapidly increasing in the U.S. and Europe. The discovery… read more here.
Keywords: mcc; cell carcinoma; cellular origin; merkel ... See more keywords
Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.277
Abstract: The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often… read more here.
Keywords: merkel; merkel cell; ligase targeting; cell polyomavirus ... See more keywords
Merkel cells touch a nerve
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0100-6
Abstract: Epidermal Merkel cells sense touch, but how they activate sensory neurons is not clear. Now, Hoffman et al. demonstrate that Merkel cells manufacture presynaptic and catecholamine-synthesis machinery, and can package and release a neurotransmitter analogue… read more here.
Keywords: merkel; cells touch; touch nerve; merkel cells ... See more keywords
Merkel III: From Committed Pragmatist to ‘Conviction Leader’?
Sign Up to like & getrecommendations! Published in 2019 at "German Politics"
DOI: 10.1080/09644008.2018.1462340
Abstract: For most of her political career Angela Merkel has been perceived as a pragmatic political leader, avoiding tough and divisive decisions wherever possible, and joining decision-making coalitions on contested issues when they emerged. To some… read more here.
Keywords: merkel iii; conviction; iii committed; conviction leader ... See more keywords
Contractual Arrangements, Formal Institutions and Personalised Crisis Management: Coalition Governance Under Chancellor Merkel (2013–2017)
Sign Up to like & getrecommendations! Published in 2019 at "German Politics"
DOI: 10.1080/09644008.2018.1512591
Abstract: The cabinet Merkel III (2013–2017) faced several exogenous challenges that called for effective conflict management in this coalition of Christian Democrats (CDU and CSU) and Social Democrats (SPD). Following the SPD’s hesitation to join the… read more here.
Keywords: coalition; 2013 2017; management; merkel ... See more keywords
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.11.503570
Abstract: Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associated neurites during skin organogenesis remains… read more here.
Keywords: merkel cells; merkel cell; atoh1a; dermal appendage ... See more keywords
Merkel cell polyomavirus is uncommon in New Zealand Merkel cell carcinomas
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Dermatology"
DOI: 10.1111/bjd.16903
Abstract: Merkel Cell Carcinoma (MCC) is a rare skin tumour with an incidence of 0.88 per 100,000 people in New Zealand (NZ), one of the highest in the world1 and almost on par with close neighbours… read more here.
Keywords: new zealand; cell polyomavirus; polyomavirus uncommon; merkel ... See more keywords
Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Anatomy"
DOI: 10.1111/joa.12688
Abstract: The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called… read more here.
Keywords: merkel cells; immunoreactivity; merkel; meissner corpuscles ... See more keywords
Piezo2 channel–Merkel cell signaling modulates the conversion of touch to itch
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aar5703
Abstract: Loss of touch receptors leads to itch Itch in response to light touch of the skin is an aging-associated problem. This phenomenon is called alloknesis and can become a major medical condition associated with dry… read more here.
Keywords: itch; dry skin; alloknesis; merkel cells ... See more keywords