Mechanosensing at the Surface
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.238
Abstract: Skin is innervated by a rich variety of mechanosensitive neurons that trigger distinct sensations such as pressure, flutter and pain. A growing body of evidence indicates that epithelial cells actively partipate in sensation by modulating,… read more here.
Keywords: mechanosensing surface; merkel cells;
Merkel cells touch a nerve
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0100-6
Abstract: Epidermal Merkel cells sense touch, but how they activate sensory neurons is not clear. Now, Hoffman et al. demonstrate that Merkel cells manufacture presynaptic and catecholamine-synthesis machinery, and can package and release a neurotransmitter analogue… read more here.
Keywords: merkel; cells touch; touch nerve; merkel cells ... See more keywords
Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.11.503570
Abstract: Touch system function requires precise interactions between specialized skin cells and somatosensory axons, as exemplified by the vertebrate mechanosensory Merkel cell-neurite complex. Development and patterning of Merkel cells and associated neurites during skin organogenesis remains… read more here.
Keywords: merkel cells; merkel cell; atoh1a; dermal appendage ... See more keywords
Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Anatomy"
DOI: 10.1111/joa.12688
Abstract: The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called… read more here.
Keywords: merkel cells; immunoreactivity; merkel; meissner corpuscles ... See more keywords
Piezo2 channel–Merkel cell signaling modulates the conversion of touch to itch
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aar5703
Abstract: Loss of touch receptors leads to itch Itch in response to light touch of the skin is an aging-associated problem. This phenomenon is called alloknesis and can become a major medical condition associated with dry… read more here.
Keywords: itch; dry skin; alloknesis; merkel cells ... See more keywords
Human fetal skin derived merkel cells display distinctive characteristics in vitro and in bio-engineered skin substitutes in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.983870
Abstract: Human skin contains specialized neuroendocrine Merkel cells responsible for fine touch sensation. In the present study, we performed in-depth analysis of Merkel cells in human fetal back skin. We revealed that these Merkel cells expressed… read more here.
Keywords: merkel cells; skin; fetal skin; human fetal ... See more keywords