Merlin deficiency alters the redox management program in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12896
Abstract: The expression of Merlin tumor suppressor protein encoded by Neurofibromin 2 (NF2) gene is remarkably decreased in metastatic breast cancer tissues. In order to recapitulate clinical evidence, we generated a unique, conditional Nf2‐knockout (Nf2−/−) mouse… read more here.
Keywords: redox management; merlin; breast; breast cancer ... See more keywords
The ERM family member Merlin is required for endometrial gland morphogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.08.006
Abstract: Disruption of endometrial gland formation or function can cause female infertility. Formation of endometrial glands via tubulogenesis of luminal epithelial cells requires the establishment and maintenance of cell polarity and cell adhesion. The FERM domain-containing… read more here.
Keywords: merlin; formation; endometrial gland; gland ... See more keywords
Merlin and expanded integrate cell signaling that regulates cyst stem cell proliferation in the Drosophila testis niche.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.05.012
Abstract: The Drosophila testis is a model organism stem cell niche in which two stem cell populations coordinate together to produce sperm; thus, these stem cells must be balanced in the niche. Merlin, a tumor-suppressor and… read more here.
Keywords: merlin; cyst; proliferation; niche ... See more keywords
LeMMINGs III. The e-MERLIN legacy survey of the Palomar sample: exploring the origin of nuclear radio emission in active and inactive galaxies through the [O iii] – radio connection
Sign Up to like & getrecommendations! Published in 2021 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stab2613
Abstract: What determines the nuclear radio emission in local galaxies? To address this question, we combine optical [O iii] line emission, robust black hole (BH) mass estimates, and high-resolution e-MERLIN 1.5-GHz data, from the LeMMINGs survey, of… read more here.
Keywords: radio emission; merlin; radio; core propto ... See more keywords
Unveiling the 100 pc scale nuclear radio structure of NGC 6217 with e-MERLIN and the VLA
Sign Up to like & getrecommendations! Published in 2019 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stz1135
Abstract: We present high-sensitivity 1.51 GHz e-MERLIN (e-Multi-Element Radio-Linked Interferometer Network) radio images of the nearby galaxy NGC6217. We resolve the compact radio source at the centre of NGC6217 for the first time, finding a twin-lobed… read more here.
Keywords: unveiling 100; merlin; radio; structure ... See more keywords
merlin, an improved framework for the reconstruction of high-quality genome-scale metabolic models
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac459
Abstract: Abstract Genome-scale metabolic models have been recognised as useful tools for better understanding living organisms’ metabolism. merlin (https://www.merlin-sysbio.org/) is an open-source and user-friendly resource that hastens the models’ reconstruction process, conjugating manual and automatic procedures,… read more here.
Keywords: scale metabolic; merlin; reconstruction; metabolic models ... See more keywords
Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adv2385
Abstract: Nitric oxide (NO) released endogenously by induced NO synthase (iNOS) in macrophages is a key regulatory biomarker for wound inflammation. Detecting NO directly on the wound bed is challenging due to its short half-life time… read more here.
Keywords: time; multiplexed electrochemical; merlin; nitric oxide ... See more keywords
Therapeutic Potential of hucMSC-EVs in Diabetic Kidney Disease via Regulating the miR-146b-5p/Merlin/YAP Axis
Sign Up to like & getrecommendations! Published in 2025 at "Stem Cells International"
DOI: 10.1155/sci/5243270
Abstract: Diabetic kidney disease (DKD) is characterized by a continuous decline in renal function and progressive fibrosis, making it a leading cause of end-stage kidney disease with limited therapeutic options. Recently, extracellular vesicles derived from mesenchymal… read more here.
Keywords: kidney disease; yap; merlin; mir 146b ... See more keywords
Association of clinical characterization of renal cell carcinoma (RCC) with merlin protein deficiency and biallelic loss of NF2 .
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.5_suppl.506
Abstract: 506 Background: Neurofibromin-2 (NF2) is a tumor suppressor gene that encodes the scaffolding protein merlin and is commonly mutated in rare RCC subtypes: unclassified (uRCC), papillary (pRCC), collecting duct carcinoma (CDCA), and the emerging entity,… read more here.
Keywords: loss; merlin; rcc; bhp rcc ... See more keywords
NEDD4L‐mediated Merlin ubiquitination facilitates Hippo pathway activation
Sign Up to like & getrecommendations! Published in 2020 at "EMBO reports"
DOI: 10.15252/embr.202050642
Abstract: The tumor suppressor Merlin/NF2, a key activator of the Hippo pathway in growth control, is regulated by phosphorylation. However, it is uncertain whether additional post‐translational modifications regulate Merlin. Here, we show that ubiquitination is required… read more here.
Keywords: merlin; merlin ubiquitination; nedd4l mediated; activation ... See more keywords
Improved Merlin–Arthur Protocols for Central Problems in Fine-Grained Complexity
Sign Up to like & getrecommendations! Published in 2023 at "Algorithmica"
DOI: 10.4230/lipics.itcs.2022.3
Abstract: In a Merlin–Arthur proof system, the proof verifier (Arthur) accepts valid proofs (from Merlin) with probability 1, and rejects invalid proofs with probability arbitrarily close to 1. The running time of such a system is… read more here.
Keywords: time; merlin; arthur time; merlin arthur ... See more keywords