Sensitive and Selective Bioscreening of the Most Commonly Used Coronavirus Disease Drug, Favipiravir, and Its Co-Administered therapeutic, Meropenem, in Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200332
Abstract: Favipiravir and Meropenem have been concurrently used as directly acting antiviral and antibiotic agents for the treatment of coronavirus disease in human plasma. Accurate and specific reversed phase ultra-performance liquid chromatographic and high performance thin… read more here.
Keywords: human plasma; coronavirus disease; meropenem; favipiravir ... See more keywords
Evaluation of Plazomicin, Tigecycline, and Meropenem Pharmacodynamic Exposure against Carbapenem-Resistant Enterobacteriaceae in Patients with Bloodstream Infection or Hospital-Acquired/Ventilator-Associated Pneumonia from the CARE Study (ACHN-490-007)
Sign Up to like & getrecommendations! Published in 2019 at "Infectious Diseases and Therapy"
DOI: 10.1007/s40121-019-0251-4
Abstract: IntroductionCARE was a Phase 3, randomized study evaluating the efficacy and safety of plazomicin-based combination therapy compared with colistin-based combination therapy for the treatment of patients with bloodstream infections or hospital-acquired/ventilator-associated pneumonia due to carbapenem-resistant… read more here.
Keywords: patients bloodstream; tigecycline meropenem; exposure; meropenem ... See more keywords
Antimicrobial resistance in the Bacteroides fragilis group in faecal samples from patients receiving broad-spectrum antibiotics.
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DOI: 10.1016/j.anaerobe.2017.04.013
Abstract: Members of the Bacteroides fragilis group are opportunistic pathogens and cause severe infections including bacteraemia. As increased levels of antimicrobial resistance in B. fragilis group bacteria can be detected years after administration of specific antibiotics, monitoring… read more here.
Keywords: fragilis group; susceptibility; group; antimicrobial resistance ... See more keywords
Continuous infusion versus intermittent administration of meropenem in critically ill patients (MERCY): A multicenter randomized double-blind trial. Rationale and design.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106346
Abstract: OBJECTIVE Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial activity against gram-negative, gram-positive and anaerobic micro-organisms and is important in the empirical treatment of serious infections in Intensive Care Unit (ICU) patients. Multi-drug resistant… read more here.
Keywords: trial; continuous infusion; drug resistant; meropenem ... See more keywords
Population Pharmacokinetic Analysis of Meropenem After Intravenous Infusion in Korean Patients With Acute Infections.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.07.001
Abstract: PURPOSE The aim of this study was to investigate the population pharmacokinetic (PK) profile of meropenem in Korean patients with acute infections. METHODS The study included 37 patients with a creatinine clearance ≤50 or >50… read more here.
Keywords: patients acute; population pharmacokinetic; acute infections; korean patients ... See more keywords
Therapeutic Target Attainment of 3-Hour Extended Infusion of Meropenem in Patients With Septic Burns.
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DOI: 10.1016/j.clinthera.2022.02.007
Abstract: PURPOSE The aim of this prospective cohort study was to evaluate the therapeutic target attainment of 3-hour extended infusion of meropenem in patients with septic burns in the early and late periods of septic shock.… read more here.
Keywords: meropenem; septic burns; patients septic; target ... See more keywords
Effect of increasing meropenem MIC on the killing activity of meropenem in combination with amikacin or polymyxin B against MBL- and KPC-producing Enterobacter cloacae.
Sign Up to like & getrecommendations! Published in 2018 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2018.06.013
Abstract: Carbapenem resistant Enterobacteriaceae (CRE) are a growing threat worldwide. Infections caused by these organisms have exhibited high rates of mortality (50%) for which there is no standard of care and a dearth of clinical trials.… read more here.
Keywords: producing enterobacter; meropenem; polymyxin; enterobacter cloacae ... See more keywords
Efficacy of ceftolozane/tazobactam, alone and in combination with colistin, against multidrug-resistant Pseudomonas aeruginosa in an in vitro biofilm pharmacodynamic model.
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DOI: 10.1016/j.ijantimicag.2019.01.010
Abstract: OBJECTIVES Ceftolozane/tazobactam is a potential tool for infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa), but its efficacy against some difficult-to-treat infections has not been well defined. METHODS Using an in vitro pharmacodynamic biofilm… read more here.
Keywords: tazobactam; combination; colistin; ceftolozane tazobactam ... See more keywords
Meropenem, levofloxacin and linezolid in human plasma of critical care patients: A fast semi‐automated micro‐extraction by packed sorbent UHPLC‐PDA method for their simultaneous determination
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.03.035
Abstract: &NA; An ultra high‐performance liquid chromatographic (UHPLC) method with PDA detection was developed and validated for the simultaneous quantification of meropenem, linezolid, and levofloxacin in human plasma and applied in human plasma of critical care… read more here.
Keywords: levofloxacin; pda; human plasma; method ... See more keywords
Determination of meropenem in endotracheal tubes by in‐tube solid phase microextraction coupled to capillary liquid chromatography with diode array detection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.01.006
Abstract: Graphical abstract Figure. No caption available. HighlightsIn‐tube SPME‐CapLC‐DAD has been evaluated to determine meropenem in ETTs.The analytical performance has been successfully demonstrated.Meropenem was found at concentrations of ng/mL.The proposed procedure is a sustainable and operational… read more here.
Keywords: phase; extraction; tube; tube spme ... See more keywords
Stability of meropenem in plasma versus dried blood spots (DBS)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.03.055
Abstract: Graphical abstract Figure. No Caption available. Abstract Meropenem, a beta‐lactam antibiotic belonging to the group of carbapenems, is widely used in the treatment of serious and complicated infections. Therapeutic drug monitoring (TDM) is strongly recommended… read more here.
Keywords: plasma; blood spots; stability meropenem; dried blood ... See more keywords