Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy
Sign Up to like & getrecommendations! Published in 2025 at "Intensive Care Medicine"
DOI: 10.1007/s00134-025-08067-w
Abstract: Optimal dosing of meropenem and piperacillin/tazobactam in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to variable pharmacokinetics. We aimed to develop generalisable optimised dosing recommendations for these antibiotics. Prospective, multinational pharmacokinetic… read more here.
Keywords: critically ill; ill patients; meropenem piperacillin; piperacillin ... See more keywords
Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 2: Stability Evaluation
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00861-18
Abstract: Although the stability of β-lactam antibiotics is a known issue, none of the previously reported bioanalytical methods had an adequate evaluation of the stability of these drugs. In the current study, the stability of cefepime,… read more here.
Keywords: piperacillin tazobactam; stability; cefepime meropenem; meropenem piperacillin ... See more keywords
Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.768438
Abstract: Introduction: Broad-spectrum beta-lactams are commonly prescribed for empirical or selective treatment of bacterial infections in children with malignancies. In the immunocompromised, appropriate concentration exposure is crucial to ensure antimicrobial efficacy. Augmented renal clearance (ARC) is… read more here.
Keywords: oncology; meropenem piperacillin; hematology; spectrum beta ... See more keywords
Evaluation of a Meropenem and Piperacillin Monitoring Program in Intensive Care Unit Patients Calls for the Regular Assessment of Empirical Targets and Easy-to-Use Dosing Decision Tools
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11060758
Abstract: The drug concentrations targeted in meropenem and piperacillin/tazobactam therapy also depend on the susceptibility of the pathogen. Yet, the pathogen is often unknown, and antibiotic therapy is guided by empirical targets. To reliably achieve the… read more here.
Keywords: piperacillin; drug concentrations; empirical targets; meropenem piperacillin ... See more keywords
Optimising Meropenem and Piperacillin Dosing in Patients Undergoing Extracorporeal Membrane Oxygenation Without Renal Dysfunction (MEPIMEX)
Sign Up to like & getrecommendations! Published in 2025 at "Antibiotics"
DOI: 10.3390/antibiotics14090939
Abstract: Background/Objectives: Antibiotic pharmacokinetics (PK) and pharmacodynamics (PD) are altered during extracorporeal membrane oxygenation (ECMO). Meropenem and piperacillin are among the most commonly prescribed antibiotics for infections in this population. However, guidance on dosage adjustments in… read more here.
Keywords: without renal; extracorporeal membrane; meropenem piperacillin; piperacillin ... See more keywords
Comparative LC-MS/MS and HPLC-UV Analyses of Meropenem and Piperacillin in Critically Ill Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2019.190210
Abstract: BACKGROUND Therapeutic drug monitoring (TDM) of beta-lactam antibiotics has become a valuable tool to guide dosing in critically ill patients. The main goal of the study was to compare two routinely used techniques for beta-lactam… read more here.
Keywords: ill patients; critically ill; meropenem piperacillin; hplc analyses ... See more keywords