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   Articles with "mertk" as a keyword



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MerTK Does Not Mediate Phagocytosis of Staphylococcus aureus but Attenuates Inflammation Induced by Staphylococcal Lipoteichoic Acid Through Blocking NF-κB Activation

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recommendations! Published in 2017 at "Inflammation"

DOI: 10.1007/s10753-017-0595-4

Abstract: Mer receptor tyrosine kinase (MerTK) expressed in macrophages is essential for phagocytosis of apoptotic cells. Here, we investigate whether MerTK is involved in the phagocytosis of Staphylococcus aureus (S. aureus) and regulation of staphylococcal lipoteichoic… read more here.

Keywords: phagocytosis; aureus; mertk; inflammation ... See more keywords
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MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy

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recommendations! Published in 2021 at "Brain Research"

DOI: 10.1016/j.brainres.2021.147525

Abstract: The NLR family pyrin domain-containing 3 (NLRP3) multiprotein complex is associated with neuroinflammation and poor prognosis after subarachnoid hemorrhage (SAH). Accumulating evidence shows that Mer tyrosine kinase (MerTK) alleviates inflammatory responses via a negative feedback… read more here.

Keywords: mertk; subarachnoid hemorrhage; activation; nlrp3 inflammasome ... See more keywords
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Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.108835

Abstract: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability. Here, we provide evidence that Mertk, a gene highly expressed by microglia that alters… read more here.

Keywords: remyelination; mertk; multiple sclerosis; activation ... See more keywords
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MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.

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recommendations! Published in 2020 at "Immunobiology"

DOI: 10.1016/j.imbio.2020.151960

Abstract: OBJECTIVE Staphylococcus aureus (S. aureus), one of Gram-positive pathogen, is frequently associated with acute lung inflammation. The central feature of S. aureus acute lung inflammation are pulmonary dysfunctioning and impeded host defence response, which cause… read more here.

Keywords: socs1 socs3; staphylococcus aureus; aureus induced; mertk ... See more keywords
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Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.

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recommendations! Published in 2019 at "Stem cell research"

DOI: 10.1016/j.scr.2018.11.003

Abstract: The human induced pluripotent stem cell (hiPSC) line RP1-FiPS4F1 generated from the patient with autosomal recessive retinitis pigmentosa (arRP) caused by homozygous Ser331Cysfs*5 mutation in Mer tyrosine kinase receptor (MERTK) was genetically corrected using CRISPR/Cas9… read more here.

Keywords: human induced; mertk; stem cell; cell ... See more keywords

PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00276

Abstract: Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such… read more here.

Keywords: mertk; biodistribution; pegylation; mertk antibody ... See more keywords
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MERTK missense variants in three patients with retinitis pigmentosa

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recommendations! Published in 2022 at "Ophthalmic Genetics"

DOI: 10.1080/13816810.2022.2113541

Abstract: ABSTRACT Background MERTK (MER proto-oncogene, tyrosine kinase) is a transmembrane protein essential in regulating photoreceptor outer segment phagocytosis. Biallelic mutations in MERTK cause retinal degeneration. Here we present the retinal phenotype of three patients with… read more here.

Keywords: mertk; retinitis pigmentosa; three patients; missense variants ... See more keywords
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Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance

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recommendations! Published in 2019 at "American Journal of Transplantation"

DOI: 10.1111/ajt.15087

Abstract: Recipient infusion of donor apoptotic cells is an emerging strategy for inducing robust transplantation tolerance. Daily clearance of billions of self‐apoptotic cells relies on homeostatic engagement of phagocytic receptors, in particular, receptors of the tyrosine… read more here.

Keywords: tolerance; apoptotic cells; mertk; receptor ... See more keywords
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Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.ade9459

Abstract: Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models of Mertk ablation… read more here.

Keywords: inflammation; mertk; degeneration; early onset ... See more keywords
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P01.13 MERTK signaling is critical for T cell proliferation and memory

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recommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"

DOI: 10.1136/jitc-2020-itoc7.26

Abstract: Background Overexpression of TAM receptors, including MERTK, in some cancers are integral for chemoresistance, proliferation and metastasis.1 Our group has previously demonstrated that T cells also express MERTK and engagement of MERTK signaling is responsible… read more here.

Keywords: mertk signaling; memory; cancer; proliferation ... See more keywords
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Abstract A140: MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

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recommendations! Published in 2018 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-17-a140

Abstract: The TAM family of receptor tyrosine kinases (RTKs) has been discovered to play a predominant role in promoting the growth, survival, and metastatic spread of several tumor types. AXL and MERTK are two TAM family… read more here.

Keywords: axl targeting; axl; mertk; resistance axl ... See more keywords