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   Articles with "mertk" as a keyword



MerTK Does Not Mediate Phagocytosis of Staphylococcus aureus but Attenuates Inflammation Induced by Staphylococcal Lipoteichoic Acid Through Blocking NF-κB Activation

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recommendations! Published in 2017 at "Inflammation"

DOI: 10.1007/s10753-017-0595-4

Abstract: Mer receptor tyrosine kinase (MerTK) expressed in macrophages is essential for phagocytosis of apoptotic cells. Here, we investigate whether MerTK is involved in the phagocytosis of Staphylococcus aureus (S. aureus) and regulation of staphylococcal lipoteichoic… read more here.

Keywords: phagocytosis; aureus; mertk; inflammation ... See more keywords

MerTK inhibits the activation of the NLRP3 inflammasome after subarachnoid hemorrhage by inducing autophagy

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recommendations! Published in 2021 at "Brain Research"

DOI: 10.1016/j.brainres.2021.147525

Abstract: The NLR family pyrin domain-containing 3 (NLRP3) multiprotein complex is associated with neuroinflammation and poor prognosis after subarachnoid hemorrhage (SAH). Accumulating evidence shows that Mer tyrosine kinase (MerTK) alleviates inflammatory responses via a negative feedback… read more here.

Keywords: mertk; subarachnoid hemorrhage; activation; nlrp3 inflammasome ... See more keywords

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.108835

Abstract: In multiple sclerosis (MS) and other neurological diseases, the failure to repair demyelinated lesions contributes to axonal damage and clinical disability. Here, we provide evidence that Mertk, a gene highly expressed by microglia that alters… read more here.

Keywords: remyelination; mertk; multiple sclerosis; activation ... See more keywords

MerTK negatively regulates Staphylococcus aureus induced inflammatory response via SOCS1/SOCS3 and Mal.

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recommendations! Published in 2020 at "Immunobiology"

DOI: 10.1016/j.imbio.2020.151960

Abstract: OBJECTIVE Staphylococcus aureus (S. aureus), one of Gram-positive pathogen, is frequently associated with acute lung inflammation. The central feature of S. aureus acute lung inflammation are pulmonary dysfunctioning and impeded host defence response, which cause… read more here.

Keywords: socs1 socs3; staphylococcus aureus; aureus induced; mertk ... See more keywords

Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.

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recommendations! Published in 2019 at "Stem cell research"

DOI: 10.1016/j.scr.2018.11.003

Abstract: The human induced pluripotent stem cell (hiPSC) line RP1-FiPS4F1 generated from the patient with autosomal recessive retinitis pigmentosa (arRP) caused by homozygous Ser331Cysfs*5 mutation in Mer tyrosine kinase receptor (MERTK) was genetically corrected using CRISPR/Cas9… read more here.

Keywords: human induced; mertk; stem cell; cell ... See more keywords

PEGylation of anti-MerTK Antibody Modulates Ocular Biodistribution.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00276

Abstract: Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such… read more here.

Keywords: mertk; biodistribution; pegylation; mertk antibody ... See more keywords

A Disintegrin and Metalloproteinase 17 Disrupts Bovine Macrophage MER Proto-Oncogene Tyrosine Kinase Integrity to Impede Apoptotic Cell Clearance and Promote Inflammation in Clinical Mastitis.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.4c09164

Abstract: In clinical mastitis of dairy cows, the abnormal accumulation of apoptotic cells (ACs) and subsequent secondary necrosis and inflammation pose significant concerns, with macrophage-mediated efferocytosis, crucial for ACs clearance, remaining unexplored in this context. In… read more here.

Keywords: mertk; integrity; mer; efferocytosis ... See more keywords

Fucoidan Alleviates Chemotherapy-Induced Peripheral Neuropathy via Activating the Gas6/MerTK Signaling Pathway to Reduce Neuroinflammation.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c09429

Abstract: Chemotherapy-induced peripheral neuropathy (CIPN), a prevalent dose-limiting toxicity in cancer chemotherapy, remains mechanistically elusive and therapeutically challenging. Neutrophil extracellular trap (NETs)-mediated neuroinflammation constitutes a critical mechanism for CIPN. Oxaliplatin was used to establish a murine… read more here.

Keywords: mertk; neuroinflammation; gas6 mertk; chemotherapy ... See more keywords

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00148

Abstract: MERTK and AXL are members of the TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases that are aberrantly expressed and have been implicated as therapeutic targets in a wide variety of human tumors. Dual… read more here.

Keywords: mertk; novel macrocyclic; cell; discovery novel ... See more keywords

Structure-Based Design of Potent and Selective MerTK Inhibitors by Modulating the Conformation of αC Helix

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recommendations! Published in 2025 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.4c03092

Abstract: Tumor-associated macrophages play an important role in cancer progression and immunosuppression, making their receptors promising therapeutic targets. MerTK, a TAM receptor, regulates macrophage efferocytosis and polarization, and its inhibition holds potential for tumor growth suppression… read more here.

Keywords: mertk; structure based; chemistry; inhibitors modulating ... See more keywords

Development of New N -{4-[(7-Chloro-5-methylpyrrolo[2,1- f ] [1,2,4]triazin-4-yl)oxy]-3-fluorophenyl}benzenesulfonamide Analogues: Exploring Anticancer Potential through MerTK Inhibition

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recommendations! Published in 2024 at "Synlett"

DOI: 10.1055/a-2360-6586

Abstract: Mer proto-oncogene tyrosine-protein kinase (MerTK), a part of the TAM (TYRO3, AXL, and MerTK) family, is directly correlated with metastasis and various types of cancers. The inhibition of this receptor is a promising strategy for… read more here.

Keywords: mertk; oxy fluorophenyl; triazin oxy; methylpyrrolo triazin ... See more keywords