Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF‐κB in glomerular mesangial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26511
Abstract: Lipopolysaccharide (LPS) released from gram‐negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS‐induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS… read more here.
Keywords: protein; methylation; prmt6; mes cells ... See more keywords
Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells
Sign Up to like & getrecommendations! Published in 2018 at "BMC Biology"
DOI: 10.1186/s12915-018-0568-6
Abstract: BackgroundThe hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z have recently been identified… read more here.
Keywords: histone variants; mes cells; prc2 dependent; gene expression ... See more keywords
Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181731
Abstract: Isoalantolactone has recently been revealed to induce apoptosis in several types of cancer. However, little is reported on its anti-tumor potential on human lung cancer. Our present study was designed to investigate its effects on… read more here.
Keywords: squamous carcinoma; mes cells; apoptosis; human lung ... See more keywords
Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells
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DOI: 10.15283/ijsc20089
Abstract: Background and Objectives Embryonic stem (ES) cells have the capacity to self-renew and generate all types of cells. MUC1-C, a cytoplasmic subunit of MUC1, is overexpressed in various carcinomas and mediates signaling pathways to regulate… read more here.
Keywords: mes cells; muc1; inhibition; stem cells ... See more keywords
MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Stem Cells"
DOI: 10.4252/wjsc.v11.i12.1130
Abstract: BACKGROUND Cardiovascular disease is the leading cause of death worldwide. Tissue repair after pathological injury in the heart remains a major challenge due to the limited regenerative ability of cardiomyocytes in adults. Stem cell-derived cardiomyocytes… read more here.
Keywords: mir 301a; mes cells; stem cell; differentiation ... See more keywords
Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.33149
Abstract: Piezo1 is a mechanosensitive (MS) ion channel with characteristic fast-inactivation kinetics. We found a slowly-inactivating MS current in mouse embryonic stem (mES) cells and characterized it throughout their differentiation into motor-neurons to investigate its components.… read more here.
Keywords: mes cells; piezo1 forms; slowly inactivating; mouse embryonic ... See more keywords