Farrerol alleviates high glucose-induced renal mesangial cell injury through the ROS/Nox4/ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108921
Abstract: Hyperproliferation and oxidative stress induced by hyperglycemia in mesangial cells plays crucial roles in the pathological process of diabetic nephropathy. Farrerol, isolated from rhododendron leaves, possesses broad anti-oxidative and anti-inflammatory properties towards several diseases, but… read more here.
Keywords: high glucose; cell injury; mesangial cell; glucose induced ... See more keywords
Microcystin Activates Renal NOX2 and Exacerbates Nonalcoholic Fatty Liver Disease-induced Ectopic Glomerulonephritis
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.285
Abstract: Clinical evidence show NAFLD results in cardiovascular, intestinal and renal complications. Previous reports from our laboratory exhibited NAFLD induced ectopic inflammatory manifestations in the kidney that gave rise to glomerular inflammation. Extending our studies, we… read more here.
Keywords: induced ectopic; microcystin; cell activation; mesangial cell ... See more keywords
β1,4-galactosyltransferase 1 is a novel receptor for IgA in human mesangial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.05.002
Abstract: IgA nephropathy is characterized by mesangial deposition of IgA, mesangial cell proliferation, and extracellular matrix production. Mesangial cells bind IgA, but the identity of all potential receptors involved remains incomplete. The transferrin receptor (CD71) acts… read more here.
Keywords: iga; galactosyltransferase; mesangial cells; mesangial cell ... See more keywords
Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13278
Abstract: Mesangial cell proliferation is the most basic pathological feature of immunoglobulin A nephropathy (IgAN); however, the specific underlying mechanism and an appropriate therapeutic strategy are yet to be unearthed. This study aimed to investigate the… read more here.
Keywords: cell proliferation; card9 p38; proliferation; mesangial cell ... See more keywords
Mesangial cell: A hub in lupus nephritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1063497
Abstract: Lupus nephritis (LN) is a severe renal disease caused by the massive deposition of the immune complexes (ICs) in renal tissue, acting as one of the significant organ manifestations of systemic lupus erythematosus (SLE) and… read more here.
Keywords: cell hub; hub lupus; mesangial cell; lupus nephritis ... See more keywords