Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR‐185/TGF‐β1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26959
Abstract: Circular RNAs (circRNAs) are a novel type of noncoding RNAs that modulate the pathogenesis of multiple diseases. Nevertheless, the role of circRNAs in diabetic nephropathy (DN) pathogenesis is still ambiguous. In the current study, our… read more here.
Keywords: mesangial cells; circrna 15698; 185 tgf; mir 185 ... See more keywords
Protective effect of cadmium-induced autophagy in rat renal mesangial cells
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DOI: 10.1007/s00204-017-2103-x
Abstract: Cadmium damages renal cells, and in particular may cause mesangial cell death by necrosis or apoptosis, depending on exposure conditions in cultured cells. However, there is an uncertainty as to whether Cd2+-induced autophagy can protect… read more here.
Keywords: mesangial cells; renal mesangial; cadmium; cell death ... See more keywords
FOXP1 inhibits high glucose-induced ECM accumulation and oxidative stress in mesangial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108818
Abstract: Diabetic nephropathy (DN) is a common complication of diabetes that remains the major cause of end-stage renal disease (ESRD). Forkhead box P1 (FOXP1) is a member of FOX family involved in the progression of diabetes.… read more here.
Keywords: mcs; ecm accumulation; mesangial cells; high glucose ... See more keywords
The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.05.019
Abstract: Renal aging and associated functional decline are associated with an increase in cellular senescence. Previous studies show a direct correlation between advanced glycation end products (AGEs) accumulation and renal aging, chronic kidney disease (CKD) and… read more here.
Keywords: mesangial cells; senescence mesangial; autophagy; rage stat5 ... See more keywords
Protective mechanisms of resveratrol derivatives against TNF‐&agr;‐induced inflammatory responses in rat mesangial cells
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DOI: 10.1016/j.cyto.2018.10.008
Abstract: Introduction: Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis… read more here.
Keywords: inflammatory responses; tnf agr; mesangial cells; protective mechanisms ... See more keywords
β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106556
Abstract: β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose… read more here.
Keywords: induced mcs; mesangial cells; high glucose; bcp ... See more keywords
β1,4-galactosyltransferase 1 is a novel receptor for IgA in human mesangial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.05.002
Abstract: IgA nephropathy is characterized by mesangial deposition of IgA, mesangial cell proliferation, and extracellular matrix production. Mesangial cells bind IgA, but the identity of all potential receptors involved remains incomplete. The transferrin receptor (CD71) acts… read more here.
Keywords: iga; galactosyltransferase; mesangial cells; mesangial cell ... See more keywords
DNA induction of MDM2 promotes proliferation of human renal mesangial cells and alters peripheral B cells subsets in pediatric systemic lupus erythematosus
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DOI: 10.1016/j.molimm.2018.01.003
Abstract: HIGHLIGHTSApoptotic and necrotic CD4+T cells are associated with plasma cell free DNA in pediatric SLE.Ds‐ISD induces MDM2 expression in human renal mesangial cells.MDM2 promotes cell proliferation in human renal mesangial cells.MDM2 alters peripheral B cells… read more here.
Keywords: human renal; dna; mdm2; proliferation ... See more keywords
Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells
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DOI: 10.1038/s41598-018-34612-3
Abstract: Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells… read more here.
Keywords: methylation tgfb1; mesangial cells; tgfb1; aberrant dna ... See more keywords
Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells
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DOI: 10.1038/s41598-019-41253-7
Abstract: Several clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on diabetic nephropathy. The underlying mechanisms are not fully understood. We found that administration of canagliflozin at a low dose (0.01 mg/kg/day)… read more here.
Keywords: sglt2 inhibitors; sglt2 mesangial; role sglt2; sglt2 ... See more keywords
Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells
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DOI: 10.1042/bsr20171061
Abstract: Little is known about the cross-talk between parathyroid hormone (PTH) related protein (PTHrP) and TGF-β1 in mesangial cells (MCs). Our results showed that PTHrP treatment (≤3 h) induced internalization of PTH1R (PTH/PTHrP receptor)–TβRII (TGF-β type… read more here.
Keywords: parathyroid hormone; mesangial cells; fibronectin regulation; related protein ... See more keywords